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New MRI Scan Method for Spinal Cord Lesions in Multiple Sclerosis

Compares a new spinal MRI scan method with standard scans in adults with multiple sclerosis.

Plain-language title generated from the registry record
Registry title: 3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)

Key facts

Where
Bordeaux, FranceSee the site

Where in France

  • CHU de BordeauxBordeaux, FranceTaking people

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Trial details

Who runs it
University Hospital, Bordeaux
Trial code
NCT05227092
Record updated
29 June 2025
Original description
The aim of this study is to compare the 3D OPTIMIZED MPRAGE WMN sequence to "conventional sequences" used in spinal cord analysis.Read full original descriptionShow less

3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)

The aim of this study is to compare the 3D OPTIMIZED MPRAGE WMN sequence to "conventional sequences" used in spinal cord analysis.

The patients will be explored at the cervical level with the conventional 2D sagittal T2 FSE, 2D sagittal STIR, 2D sagittal PSIR, 3D T1 MPRAGE sequences, and the sequence of interest 3D sagittal OPTIMIZED WMN MPRAGE and 3D axial OPTIMIZED WMN MPRAGE. At the thoracic level, with the conventional 2D sagittal T2 FSE, 2D sagittal STIR, 3D T1 MPRAGE sequences and the sequence of interest 3D sagittal OPTIMIZED WMN MPRAGE.

Inclusion: Patients older than 18 years old; CIS or RRMS; Medullary symptomatology less than 6 months; With or without an objective lesion on a subsequent MRI scan; Signed the Informed Consent.

Exclusion: Surgical history on the spinal cord or lumbar spine; Other diagnosis (Neuro-myelitis spectrum disease or Progressive Multiple Sclerosis); Pregnant or potentially pregnant women; Breastfeeding woman; Contraindications to MRI; Patient under legal protection.

ClinicalTrials.gov NCT05227092