CompletedNo phase
High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus
Key facts
- Who runs it
- Nantes University Hospital
- Where
- France15 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 110 people enrolled
- Started
- 11 May 2022
- Ended
- 19 Feb 2025
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Electronic chromoendoscopy
- White light endoscopy with Seattle protocol
- Record updated
- 14 November 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Male or Female with Age above ≥ years old
- Female of childbearing potential must use appropriate method(s) of contraception during the clinical trial (i.e.: Intrauterine Device, pill, implant,sexual abstinence)
- Dysplastic Barrett's Esophagus preferably labelled "flat mucosal dysplasia"
- Patient requiring esophageal endoscopy as part of their regular monitoring
- Affiliated to social security
- Patient received Patient Information Form and accepted to participate to the study
Who cannot take part
- Previously treated Barrett's Esophagus
- Ongoing clopidogrel or anticoagulant therapy or coagulation disorder (platelet count < 50 000/mm3, Prothrombin time ratio <50%)
- Known invasive esophageal adenocarcinoma
- Contraindication to general anesthesia
- Poor general health status precluding subsequent follow up of Barrett's Esophagus
- For female: pregnancy or breastfeeding
- Adults under a legal protection regime (guardianship, trusteeship, "under judicial protection")
- Ongoing participation in another study requiring an intervention on Barrett's Esophagus during patient's participation in Converse study
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The investigators hypothesize that careful examination of Barrett's esophagus by high-resolution endoscopy combined with virtual chromoendoscopy could replace the Seattle protocol for Barrett's esophagus monitoring and detection of dysplasic lesions, and thus modify existing recommendations.
The 2 groups in the trial
- Electronic chromoendoscopyTreatment being tested
High-resolution endoscopy combined with virtual chromoendocopy to detect esophageal displasic lesions
- White light endoscopy with Seattle protocolExisting treatment, for comparison
White light endoscopy to detect esophageal displasic lesions, and then systemic quadrantic biopsies every 2 centimeters from the esogastric junction to the top of the Barett's esophagus (Seattle protocol)
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus: Impact on the Detection of High-grade Dysplasia and Adenocarcinoma Lesions
- Publications
- Record updated
- 14 November 2025