Tests home air purifiers in adults with heart failure
Tests portable air filters in adults with heart failure and reduced ejection fraction.
Plain-language title generated from the registry record
Registry title: The PURI-HF (Air Purifiers on Heart Failure) Trial
Key facts
- Where
- Delhi, Ludhiana, and Thiruvananthapuram, IndiaSee the 3 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with heart failure and a weak pumping heart (reduced ejection fraction) in India. It tests whether home air purifiers help.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Heart failure diagnosed within the last six months, with reduced ejection fraction of ≤ 40%, in NYHA class II-IV
- Earlier treatment
- Must not have had a CRT device implanted in the last 3 months
- Biomarker or test result
- Ejection fraction of ≤ 40%
Main reasons for not taking part
- Listed for a heart transplant
- CRT device implanted in the last 3 months
- On oxygen therapy
- Severe lung disease
- Unable to walk
Read by machine on 12 November 2026.
Where in India
- All India Institute of Medical Sciences (AIIMS)Delhi, IndiaContact: Rajesh Vedanthan, MD, MPHTaking people
- Public Health Foundation of India (PHFI)Ludhiana, IndiaContact: Rajesh Vedanthan, MD, MPHTaking people
- Centre for Chronic Disease Control (CCDC)Thiruvananthapuram, IndiaContact: Rajesh Vedanthan, MD, MPHTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- NYU Langone Health
- Trial code
- NCT05230784
- Record updated
- 29 January 2026
- Original description
Indoor air pollution and fine mode particulate matter with an aerodynamic diameter smaller than 2.5 micrometers (PM2.5) is a major contributor to global morbidity and mortality, particularly due to cardiovascular disease. This project aims to demonstrate the efficacy, feasibility and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India. The findings from the project will add to existing knowledge of innovative and scalable strategies to improve environmental and cardiovascular health worldwide.Read full original descriptionShow less
Effectiveness of Indoor Air Purifiers on Heart Failure Outcomes
Indoor air pollution and fine mode particulate matter with an aerodynamic diameter smaller than 2.5 micrometers (PM2.5) is a major contributor to global morbidity and mortality, particularly due to cardiovascular disease. This project aims to demonstrate the efficacy, feasibility and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India. The findings from the project will add to existing knowledge of innovative and scalable strategies to improve environmental and cardiovascular health worldwide.
The overall objective of this study is to demonstrate the efficacy, feasibility, and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India.
Inclusion: Adults ≥ 18 years of age diagnosed with HF with a reduced ejection fraction of ≤ 40% within the last six months in NYHA class II-IV.
Exclusion: on oxygen therapy; listed for a cardiac transplant; history of CRT device implantation in last 3 months; with severe pulmonary disease; participants unable to ambulate.