Compares simpler and standard brain imaging to choose stroke clot removal
Tests simpler brain scans against standard imaging in adults with stroke.
Plain-language title generated from the registry record
Registry title: A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
Key facts
- Where
- Chongqing, Dalian, Haikou, Huai'an, Jiangmen, Jingdezhen, Wuhu, and Wuxi, ChinaSee the 8 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a sudden stroke, seen within 24 hours of last being well. It compares two ways of using brain scans to choose people for clot-removal treatment.
- Age
- 18 years or older
- Sex
- Men and women
- Disease stage
- Acute stroke confirmed by symptoms or imaging, with a FAST ED score of 4 or more. The summary mentions a blockage of a large artery in the front part of the brain.
Main reasons for not taking part
- Allergy to contrast agents used in imaging, or to nitinol devices
- Currently pregnant or breastfeeding
- Blockage of more than one blood vessel
- Brain tumour with mass effect (except meningioma), aneurysm or arteriovenous malformation
- Any terminal illness with life expectancy under 6 months
Read by machine on 12 November 2026.
Where in China
- Xinqiao Hospital of Army Medical UniversityChongqing, ChinaContact: Zhongming Qiu, MDNot yet recruiting
- Dalian Central HospitalDalian, ChinaContact: Zhongjun Chen, MDTaking people
- The First Affiliated Hospital of Hainan Medical UniversityHaikou, ChinaContact: Zhenqiang Zhao, MDTaking people
- Huai'an First People's HospitalHuai'an, ChinaContact: Mingchao Li, MSTaking people
- Wuyi Traditional Chinese Medicine HospitalJiangmen, ChinaContact: Tao Yu, MDNot yet recruiting
- Jingdezhen First People's HospitalJingdezhen, ChinaContact: Shunfu Jiang, MSTaking people
- Yijishan Hospital of Wannan Medical CollegeWuhu, ChinaContact: Zhiming Zhou, MDTaking people
- The 904th Hospital of CPLAWuxi, ChinaContact: Zhonghua Shi, MDNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Xinqiao Hospital of Chongqing
- Trial code
- NCT05230914
- Record updated
- 26 December 2025
- Original description
Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy.Read full original descriptionShow less
Simple Imaging Versus Standard Imaging Selection in Stroke Patients for Endovascular Treatment: the NO-SELECT Randomized Trial
Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy.
The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.
Inclusion: Aged 18 years or older; The interval time from last known well to hospital arrival is within 24 hours; Acute stroke confirmed by clinical symptoms or imaging examination; Field Assessment Stroke Triage for Emergency Destination (FAST ED) ≥4; Written informed consent is obtained from patients and/or their legal representatives.
Exclusion: Allergy to radiographic contrast agents, or nitinol devices; Arterial tortuosity and/or other arterial disease that would prevent the device from reaching the target vessel; Preexisting neurological or psychiatric disease that would confound the neurological functional evaluations; Any terminal illness with life expectancy less than 6 months; Currently pregnant or lactating (women patients); Multiple vessel occlusion (e.g., bilateral anterior circulation, or occlusion of both anterior and posterior circulation); Brain tumors with mass effect (except meningiomas) that are radiographically pleasant; Intracranial aneurysm, arteriovenous malformation; Unlikely to be available for 90-day follow-up.