Compares simpler and standard brain imaging to choose stroke clot removal
Tests simpler brain scans against standard imaging in adults with stroke.
Plain-language title generated from the registry record
Registry title: A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
Key facts
- Where
- Chongqing, Dalian, Haikou, Huai'an, Jiangmen, Jingdezhen, Wuhu, and Wuxi, ChinaSee the 8 sites
Where in China
- Xinqiao Hospital of Army Medical UniversityChongqing, ChinaNot yet recruiting
- Dalian Central HospitalDalian, ChinaTaking people
- The First Affiliated Hospital of Hainan Medical UniversityHaikou, ChinaTaking people
- Huai'an First People's HospitalHuai'an, ChinaTaking people
- Wuyi Traditional Chinese Medicine HospitalJiangmen, ChinaNot yet recruiting
- Jingdezhen First People's HospitalJingdezhen, ChinaTaking people
- Yijishan Hospital of Wannan Medical CollegeWuhu, ChinaTaking people
- The 904th Hospital of CPLAWuxi, ChinaNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Xinqiao Hospital of Chongqing
- Trial code
- NCT05230914
- Record updated
- 26 December 2025
- Original description
Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy.Read full original descriptionShow less
Simple Imaging Versus Standard Imaging Selection in Stroke Patients for Endovascular Treatment: the NO-SELECT Randomized Trial
Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy.
The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.
Inclusion: Aged 18 years or older; The interval time from last known well to hospital arrival is within 24 hours; Acute stroke confirmed by clinical symptoms or imaging examination; Field Assessment Stroke Triage for Emergency Destination (FAST ED) ≥4; Written informed consent is obtained from patients and/or their legal representatives.
Exclusion: Allergy to radiographic contrast agents, or nitinol devices; Arterial tortuosity and/or other arterial disease that would prevent the device from reaching the target vessel; Preexisting neurological or psychiatric disease that would confound the neurological functional evaluations; Any terminal illness with life expectancy less than 6 months; Currently pregnant or lactating (women patients); Multiple vessel occlusion (e.g., bilateral anterior circulation, or occlusion of both anterior and posterior circulation); Brain tumors with mass effect (except meningiomas) that are radiographically pleasant; Intracranial aneurysm, arteriovenous malformation; Unlikely to be available for 90-day follow-up.