Taking people in United StatesPhase 3
Compares two chest surgeries for bone cancer that has spread to the lungs
Compares open chest surgery with keyhole surgery in people with osteosarcoma spread to lungs.
Plain-language title generated from the registry record
Registry title: Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
Key facts
- Where
- Akron, Albany, Albuquerque, Allentown, Amarillo, Anaheim, Anchorage, Ann Arbor, Arroyo Grande, Asheville, Atlanta, Aurora, Austin, Baltimore, Bangor, Battle Creek, Bellevue, Bellflower, Bethesda, Birmingham, Boise, Boston, Brooklyn, Burlington, Carson City, Chapel Hill, Charleston, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Corpus Christi, Dallas, Danville, Dayton, Denver, Des Moines, Detroit, Downey, Durham, East Lansing, El Paso, Falls Church, Fargo, Fontana, Fort Myers, Fort Worth, Gainesville, Grand Rapids, Greenville, Hackensack, Hartford, Henderson, Hershey, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kalamazoo, Kansas City, Kingman, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Loma Linda, Long Beach, Los Angeles, Louisville, Madera, Madison, Marshfield, Maywood, Memphis, Mesa, Miami, Milwaukee, Minneapolis, Morgantown, Morristown, Muskegon, Nashville, New Brunswick, New Haven, New Hyde Park, New Orleans, New York, Niles, Norfolk, Norton Shores, Oakland, Oklahoma City, Omaha, Orange, Orlando, Pahrump, Palo Alto, Paterson, Peoria, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reed City, Reno, Renton, Richmond, Roanoke, Rochester, Royal Oak, Sacramento, Saint Joseph, Salt Lake City, San Antonio, San Diego, San Francisco, Scarborough, Seattle, Sioux Falls, Spokane, St Louis, St. Petersburg, Stony Brook, Syracuse, Tacoma, Tampa, The Bronx, Toledo, Traverse City, Tucson, Valhalla, Washington D.C., Wilmington, Winfield, Winston-Salem, Wyoming, and Yakima, United StatesSee the 220 sites
- Phase
- Phase 3
Where in United States
- Children's Hospital Medical Center of AkronAkron, United StatesTaking people
- Albany Medical CenterAlbany, United StatesTaking people
- Presbyterian HospitalAlbuquerque, United StatesTaking people
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
- Texas Tech University Health Sciences Center-AmarilloAmarillo, United StatesNo longer taking part
- Kaiser Permanente-AnaheimAnaheim, United StatesTaking people
- Providence Alaska Medical CenterAnchorage, United StatesTaking people
- C S Mott Children's HospitalAnn Arbor, United StatesTaking people
- University of Michigan Rogel Cancer CenterAnn Arbor, United StatesTaking people
- PCR OncologyArroyo Grande, United StatesTaking people
- Mission HospitalAsheville, United StatesTaking people
- Children's Healthcare of Atlanta - Arthur M Blank HospitalAtlanta, United StatesTaking people
- Children's Hospital ColoradoAurora, United StatesTaking people
- Dell Children's Medical Center of Central TexasAustin, United StatesTaking people
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesTaking people
- Sinai Hospital of BaltimoreBaltimore, United StatesTaking people
- University of Maryland/Greenebaum Cancer CenterBaltimore, United StatesTaking people
- Eastern Maine Medical CenterBangor, United StatesTaking people
- Bronson Battle CreekBattle Creek, United StatesTaking people
- Overlake Medical CenterBellevue, United StatesNo longer taking part
- Kaiser Permanente-BellflowerBellflower, United StatesTaking people
- Walter Reed National Military Medical CenterBethesda, United StatesTaking people
- Children's Hospital of AlabamaBirmingham, United StatesTaking people
- Saint Luke's Cancer Institute - BoiseBoise, United StatesTaking people
- Dana-Farber Cancer InstituteBoston, United StatesTaking people
- Massachusetts General Hospital Cancer CenterBoston, United StatesTaking people
- Maimonides Medical CenterBrooklyn, United StatesTaking people
- University of Vermont and State Agricultural CollegeBurlington, United StatesNo longer taking part
- Carson Tahoe Regional Medical CenterCarson City, United StatesTaking people
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- University of Virginia Cancer CenterCharlottesville, United StatesTaking people
- Lurie Children's Hospital-ChicagoChicago, United StatesTaking people
- University of Chicago Comprehensive Cancer CenterChicago, United StatesTaking people
- University of IllinoisChicago, United StatesTaking people
- Cincinnati Children's Hospital Medical CenterCincinnati, United StatesTaking people
- Cleveland Clinic FoundationCleveland, United StatesTaking people
- Rainbow Babies and Childrens HospitalCleveland, United StatesTaking people
- Prisma Health Richland HospitalColumbia, United StatesTaking people
- University of Missouri Children's HospitalColumbia, United StatesTaking people
- Nationwide Children's HospitalColumbus, United StatesTaking people
- Driscoll Children's HospitalCorpus Christi, United StatesTaking people
- Medical City Dallas HospitalDallas, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesTaking people
- Geisinger Medical CenterDanville, United StatesTaking people
- Dayton Children's HospitalDayton, United StatesTaking people
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterDenver, United StatesTaking people
- Blank Children's HospitalDes Moines, United StatesTaking people
- Children's Hospital of MichiganDetroit, United StatesTaking people
- Kaiser Permanente Downey Medical CenterDowney, United StatesTaking people
- Duke University Medical CenterDurham, United StatesTaking people
- Michigan State UniversityEast Lansing, United StatesNo longer taking part
- El Paso Children's HospitalEl Paso, United StatesTaking people
- Inova Fairfax HospitalFalls Church, United StatesTaking people
- Sanford Broadway Medical CenterFargo, United StatesTaking people
- Kaiser Permanente-FontanaFontana, United StatesTaking people
- Golisano Children's Hospital of Southwest FloridaFort Myers, United StatesTaking people
- Cook Children's Medical CenterFort Worth, United StatesTaking people
- UF Health Cancer Institute - GainesvilleGainesville, United StatesNo longer taking part
- Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, United StatesTaking people
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, United StatesTaking people
- Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
- BI-LO Charities Children's Cancer CenterGreenville, United StatesTaking people
- East Carolina UniversityGreenville, United StatesTaking people
- Hackensack University Medical CenterHackensack, United StatesTaking people
- Connecticut Children's Medical CenterHartford, United StatesTaking people
- Comprehensive Cancer Centers of Nevada - HendersonHenderson, United StatesTaking people
- Comprehensive Cancer Centers of Nevada-Horizon RidgeHenderson, United StatesTaking people
- Comprehensive Cancer Centers of Nevada-Southeast HendersonHenderson, United StatesTaking people
- Oncology Las Vegas - HendersonHenderson, United StatesTaking people
- Urology Specialists of Nevada - Green ValleyHenderson, United StatesTaking people
- Las Vegas Cancer Center-HendersonHenderson, United StatesNo longer taking part
- Las Vegas Urology - Green ValleyHenderson, United StatesNo longer taking part
- Las Vegas Urology - PebbleHenderson, United StatesNo longer taking part
- Penn State Children's HospitalHershey, United StatesTaking people
- Kapiolani Medical Center for Women and ChildrenHonolulu, United StatesTaking people
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHouston, United StatesTaking people
- UT MD Anderson Cancer CenterHouston, United StatesTaking people
- Riley Hospital for ChildrenIndianapolis, United StatesTaking people
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesTaking people
- University of Mississippi Medical CenterJackson, United StatesTaking people
- Nemours Children's Clinic-JacksonvilleJacksonville, United StatesTaking people
- Beacon KalamazooKalamazoo, United StatesTaking people
- Beacon Kalamazoo Cancer CenterKalamazoo, United StatesTaking people
- Bronson Methodist HospitalKalamazoo, United StatesTaking people
- West Michigan Cancer CenterKalamazoo, United StatesTaking people
- Children's Mercy Hospitals and ClinicsKansas City, United StatesTaking people
- Kingman Regional Medical CenterKingman, United StatesTaking people
- East Tennessee Childrens HospitalKnoxville, United StatesTaking people
- Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas Vegas, United StatesTaking people
- Comprehensive Cancer Centers of NevadaLas Vegas, United StatesTaking people
- Comprehensive Cancer Centers of Nevada - Central ValleyLas Vegas, United StatesTaking people
- Comprehensive Cancer Centers of Nevada - NorthwestLas Vegas, United StatesTaking people
- Comprehensive Cancer Centers of Nevada - Town CenterLas Vegas, United StatesTaking people
- Comprehensive Cancer Centers of Nevada-SummerlinLas Vegas, United StatesTaking people
- Hope Cancer Care of NevadaLas Vegas, United StatesTaking people
- Oncology Las Vegas - TenayaLas Vegas, United StatesTaking people
- OptumCare Cancer Care at CharlestonLas Vegas, United StatesTaking people
- OptumCare Cancer Care at Fort ApacheLas Vegas, United StatesTaking people
- OptumCare Cancer Care at MountainViewLas Vegas, United StatesTaking people
- Radiation Oncology Centers of Nevada CentralLas Vegas, United StatesTaking people
- Radiation Oncology Centers of Nevada SoutheastLas Vegas, United StatesTaking people
- Summerlin Hospital Medical CenterLas Vegas, United StatesTaking people
- Sunrise Hospital and Medical CenterLas Vegas, United StatesTaking people
- University Medical Center of Southern NevadaLas Vegas, United StatesTaking people
- Urology Specialists of Nevada - CentralLas Vegas, United StatesTaking people
- Urology Specialists of Nevada - NorthwestLas Vegas, United StatesTaking people
- Urology Specialists of Nevada - SouthwestLas Vegas, United StatesTaking people
- Ann M Wierman MD LTDLas Vegas, United StatesNo longer taking part
- Las Vegas Cancer Center-Medical CenterLas Vegas, United StatesNo longer taking part
- Las Vegas Urology - Cathedral RockLas Vegas, United StatesNo longer taking part
- Las Vegas Urology - PecosLas Vegas, United StatesNo longer taking part
- Las Vegas Urology - Smoke RanchLas Vegas, United StatesNo longer taking part
- Las Vegas Urology - SunsetLas Vegas, United StatesNo longer taking part
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, United StatesTaking people
- University of Kentucky/Markey Cancer CenterLexington, United StatesTaking people
- Arkansas Children's HospitalLittle Rock, United StatesTaking people
- Loma Linda University Medical CenterLoma Linda, United StatesTaking people
- Miller Children's and Women's Hospital Long BeachLong Beach, United StatesTaking people
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Children's Hospital Los AngelesLos Angeles, United StatesTaking people
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesTaking people
- Norton Children's HospitalLouisville, United StatesTaking people
- Valley Children's HospitalMadera, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, United StatesTaking people
- Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
- Loyola University Medical CenterMaywood, United StatesTaking people
- Saint Jude Children's Research HospitalMemphis, United StatesTaking people
- Banner Children's at DesertMesa, United StatesTaking people
- Nicklaus Children's HospitalMiami, United StatesTaking people
- Children's Hospital of WisconsinMilwaukee, United StatesTaking people
- Children's Hospitals and Clinics of Minnesota - MinneapolisMinneapolis, United StatesTaking people
- University of Minnesota/Masonic Cancer CenterMinneapolis, United StatesTaking people
- West Virginia University HealthcareMorgantown, United StatesTaking people
- Morristown Medical CenterMorristown, United StatesTaking people
- Trinity Health Muskegon HospitalMuskegon, United StatesTaking people
- The Children's Hospital at TriStar CentennialNashville, United StatesTaking people
- Vanderbilt University/Ingram Cancer CenterNashville, United StatesTaking people
- Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University HospitalNew Brunswick, United StatesTaking people
- Saint Peter's University HospitalNew Brunswick, United StatesTaking people
- Smilow Cancer Center/Yale-New Haven HospitalNew Haven, United StatesTaking people
- Yale UniversityNew Haven, United StatesTaking people
- The Steven and Alexandra Cohen Children's Medical Center of New YorkNew Hyde Park, United StatesTaking people
- Children's Hospital New OrleansNew Orleans, United StatesTaking people
- Ochsner Medical Center JeffersonNew Orleans, United StatesTaking people
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, United StatesTaking people
- Memorial Sloan-Kettering Cancer CenterNew York, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesTaking people
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, United StatesTaking people
- Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
- Children's Hospital of The King's DaughtersNorfolk, United StatesTaking people
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesNo longer taking part
- Kaiser Permanente-OaklandOakland, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Children's Hospital and Medical Center of OmahaOmaha, United StatesTaking people
- University of Nebraska Medical CenterOmaha, United StatesTaking people
- Children's Hospital of Orange CountyOrange, United StatesTaking people
- Arnold Palmer Hospital for ChildrenOrlando, United StatesTaking people
- Nemours Children's HospitalOrlando, United StatesTaking people
- Hope Cancer Care of Nevada-PahrumpPahrump, United StatesTaking people
- Lucile Packard Children's Hospital Stanford UniversityPalo Alto, United StatesTaking people
- Saint Joseph's Regional Medical CenterPaterson, United StatesTaking people
- OSF Children's Hospital of IllinoisPeoria, United StatesTaking people
- Saint Christopher's Hospital for ChildrenPhiladelphia, United StatesTaking people
- Phoenix Childrens HospitalPhoenix, United StatesTaking people
- Children's Hospital of Pittsburgh of UPMCPittsburgh, United StatesTaking people
- Legacy Emanuel Children's HospitalPortland, United StatesTaking people
- Oregon Health and Science UniversityPortland, United StatesTaking people
- Rhode Island HospitalProvidence, United StatesTaking people
- Corewell Health Reed City HospitalReed City, United StatesTaking people
- Renown Regional Medical CenterReno, United StatesTaking people
- Saint Mary's Regional Medical CenterReno, United StatesTaking people
- Northern Nevada Radiation OncologyReno, United StatesNo longer taking part
- Radiation Oncology AssociatesReno, United StatesNo longer taking part
- Valley Medical CenterRenton, United StatesTaking people
- VCU Massey Cancer Center at Stony PointRichmond, United StatesTaking people
- VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
- Carilion Children'sRoanoke, United StatesTaking people
- Mayo Clinic in RochesterRochester, United StatesTaking people
- Corewell Health Children'sRoyal Oak, United StatesTaking people
- University of California Davis Comprehensive Cancer CenterSacramento, United StatesTaking people
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
- Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, United StatesTaking people
- Primary Children's HospitalSalt Lake City, United StatesTaking people
- Children's Hospital of San AntonioSan Antonio, United StatesTaking people
- Methodist Children's Hospital of South TexasSan Antonio, United StatesTaking people
- University of Texas Health Science Center at San AntonioSan Antonio, United StatesTaking people
- Kaiser Permanente-San Diego ZionSan Diego, United StatesTaking people
- Rady Children's Hospital - San DiegoSan Diego, United StatesTaking people
- UCSF Medical Center-Mission BaySan Francisco, United StatesTaking people
- Maine Children's Cancer ProgramScarborough, United StatesTaking people
- Seattle Children's HospitalSeattle, United StatesTaking people
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesTaking people
- Providence Sacred Heart Medical Center and Children's HospitalSpokane, United StatesTaking people
- Cardinal Glennon Children's Medical CenterSt Louis, United StatesTaking people
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Washington University School of MedicineSt Louis, United StatesTaking people
- Johns Hopkins All Children's HospitalSt. Petersburg, United StatesTaking people
- Stony Brook University Medical CenterStony Brook, United StatesTaking people
- State University of New York Upstate Medical UniversitySyracuse, United StatesTaking people
- Madigan Army Medical CenterTacoma, United StatesTaking people
- Mary Bridge Children's Hospital and Health CenterTacoma, United StatesTaking people
- Saint Joseph's Hospital/Children's Hospital-TampaTampa, United StatesTaking people
- Tampa General HospitalTampa, United StatesTaking people
- Children's Hospital at MontefioreThe Bronx, United StatesTaking people
- Montefiore Medical Center - Moses CampusThe Bronx, United StatesTaking people
- Montefiore Medical Center-Einstein CampusThe Bronx, United StatesTaking people
- Montefiore Medical Center-Weiler HospitalThe Bronx, United StatesTaking people
- ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalToledo, United StatesTaking people
- Munson Medical CenterTraverse City, United StatesTaking people
- Banner University Medical Center - TucsonTucson, United StatesTaking people
- New York Medical CollegeValhalla, United StatesTaking people
- Westchester Medical CenterValhalla, United StatesNo longer taking part
- Children's National Medical CenterWashington D.C., United StatesTaking people
- Alfred I duPont Hospital for ChildrenWilmington, United StatesTaking people
- Northwestern Medicine Central DuPage HospitalWinfield, United StatesTaking people
- Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
- University of Michigan Health - WestWyoming, United StatesTaking people
- North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Children's Oncology Group
- Trial code
- NCT05235165
- Record updated
- 25 August 2026
- Original description
This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.Read full original descriptionShow less
A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.
Inclusion: Patients must be < 50 years at the time of enrollment; Patients must have =< 4 nodules per lung consistent with or suspicious for metastases, with at least one of which being >= 3 mm and all of which must be =< 3 cm size; Note: Patient must have eligibility confirmed by rapid central imaging review; Lung nodules must be considered resectable by either open thoracotomy or thoracoscopic surgery. Determination of resectability is made by the institutional surgeon; Patients must have a histological diagnosis of osteosarcoma; Patients must have evidence of metastatic lung disease at the time of initial diagnosis, or at time of 1st recurrence following completion of therapy for initially localized disease; Patients with newly diagnosed disease must have completed successful gross tumor resection for their primary tumor or surgical local control of primary tumor must be planned to be performed simultaneously with thoracic surgery; Newly diagnosed patients must be receiving or recently completed (within 60 days) systemic therapy considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation; Patients at time of 1st recurrence must have completed systemic therapy for their initial primary tumor, considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation.
Exclusion: Patients with pulmonary metastatic lesions that would require anatomic resection (lobectomy or pneumonectomy) or lesions that are defined as "central" (i.e., central lesion involves or is proximal to segmental bronchi and peripheral is lesion distal to segmental bronchi); Patients with disease progression at either the primary or pulmonary metastatic site while on initial therapy. Note: Once the patient has been enrolled on the study, additional computed tomography (CT) scans are not anticipated prior to thoracic surgery. Note: Some variation in nodule size measurements over the course of pre-operative therapy is anticipated and does not qualify for exclusion unless deemed true disease progression by the primary treatment team; Patients who received therapeutic pulmonary surgery for lung metastasis prior to enrollment; Patients with evidence of extrapulmonary metastatic disease; All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met; Patients with unresectable primary tumor; Patients with chest wall or mediastinal based metastatic lesions, or with significant pleural effusion; All patients and/or their parents or legal guardians must sign a written informed consent.