Childhood trauma and stress hormones in women with obesity
Studies whether childhood trauma relates to stress hormone patterns in adult women with obesity.
Plain-language title generated from the registry record
Registry title: Childhood Traumas in Obese Women: Association With Deregulation of the Glucocorticoid Axis and Inflammatory State.
Key facts
- Where
- Limoges, FranceSee the site
Where in France
- LimogesUniversity HospitalLimoges, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Limoges
- Trial code
- NCT05237440
- Record updated
- 26 June 2026
- Original description
We postulate that childhood traumas are associated with deregulation of the glucocorticoid axis and the inflammatory system in obese women. The main objective of the study is to compare the salivary cortisol awaking response in obese women according to the presence of childhood trauma (assessed using the Childhood Trauma Questionnaire, CTQ).Read full original descriptionShow less
Childhood Traumas in Obese Women: Association With Deregulation of the Glucocorticoid Axis and Inflammatory State.
We postulate that childhood traumas are associated with deregulation of the glucocorticoid axis and the inflammatory system in obese women. The main objective of the study is to compare the salivary cortisol awaking response in obese women according to the presence of childhood trauma (assessed using the Childhood Trauma Questionnaire, CTQ).
Inclusion: ≥18 years female BMI≥30kg/m2.
Exclusion: Subjects with a positive diagnosis of hypercorticism or suspected hypercorticism will also be excluded: 8-hour plasma cortisol after Dexamethasone suppression test (DST) (1 mg dexamethasone taken orally at midnight the previous day) greater than 1.8 microg/100 ml (50 nmol/l); treatment(s) likely to modify the exploration of the corticotropic axis: systemic or local corticosteroid therapy or glucocorticoid infiltration for less than 6 months; current use of anti-inflammatory drugs or antibiotics; History of bariatric surgery; Any condition or pathology that may influence the corticotropic axis or that may modify the excretion or dosage of cortisol:; pregnancy, breastfeeding; hepatocellular insufficiency,; severe heart failure,; mild/moderate acute heart failure,; any psychological disorder not stabilised for at least one year; alcohol or drug dependence, not weaned for at least one year; neoplasm under treatment; Current infectious disease or a history of autoimmune disease (except autoimmune hypothyroidism), inflammatory disease and/or neurodegenerative disease; Presence of an adrenal adenoma or any known or suspected clinical adrenal or corticotropic disorder; antidepressant and neuroleptic treatment, benzodiazepine treatment; Shift worker.