Studies blood stem cells in people with clonal hematopoiesis undergoing hip surgery
Collects bone marrow and blood cells from adults having hip surgery to study them.
Plain-language title generated from the registry record
Registry title: Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
Key facts
- Where
- Bonheiden, BelgiumSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for older adults having hip replacement surgery. Bone marrow and blood samples will be collected to study blood stem cell changes linked to aging.
- Age
- 65 years and older (the record also lists a minimum age of 55 years).
- Sex
- All sexes can join.
Main reasons for not taking part
- Known blood condition (myelodysplasia, leukemia, cancer)
- Cannot give written informed consent
Read by machine on 12 November 2026.
Where in Belgium
- Imelda HospitalBonheiden, BelgiumContact: Michaël R. Laurent, MD PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Imelda Hospital, Bonheiden
- Trial code
- NCT05246813
- Record updated
- 25 March 2026
- Original description
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.Read full original descriptionShow less
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP): a Prospective Observational Study
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.
Inclusion: Age 65 years and older.
Exclusion: known haematological condition (myelodysplasia, leukemia, cancer); inability to provide written informed consent.