Studies blood flow in the brain and thinking skills in people with heart failure
Observes heart failure patients' brain blood flow with ultrasound and thinking tests.
Plain-language title generated from the registry record
Registry title: TRAnscranial Doppler CErebral Blood Flow and Cognitive IMPAIRment in Heart Failure
Key facts
- Where
- Krakow, PolandSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with stable, long-standing heart failure. It studies how blood flow in the neck and brain relates to memory and thinking.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Clinically stable heart failure (NYHA I-III symptoms) for at least 6 months, caused by reduced blood supply to the heart, inflammation, or an inherited heart muscle disease
Main reasons for not taking part
- Severe, irreversible illness such as advanced cancer
- Previously diagnosed dementia
- Acute, decompensated heart failure
- Stroke in the last 3 months
- Anemia with hemoglobin below 8 g/dl
Read by machine on 9 November 2026.
Where in Poland
- Department of Cardiac and Vascular Diseases, The John Paul II HospitalKrakow, PolandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- John Paul II Hospital, Krakow
- Trial code
- NCT05250349
- Record updated
- 22 February 2022
- Original description
TRACE-IMPAIR is a prospective, clinical study of consecutive patients that evaluates the relationship between heart failure (HF) and cognitive impairment in relation to carotid and cerebral flow. The carotid and cerebral flow will be assessed using Doppler ultrasonography, and cognitive function will be estimated during routine neuropsychological tests.Read full original descriptionShow less
TRAnscranial Doppler CErebral Blood Flow and Cognitive IMPAIRment in Patients With Heart Failure and Presence/Absence of Atherosclerotic Carotid Artery Stenosis
TRACE-IMPAIR is a prospective, clinical study of consecutive patients that evaluates the relationship between heart failure (HF) and cognitive impairment in relation to carotid and cerebral flow. The carotid and cerebral flow will be assessed using Doppler ultrasonography, and cognitive function will be estimated during routine neuropsychological tests.
It is an observational, three(natural)-group, single-center study. It is also an Academic Registry - the scientific activity of the Faculty of Medicine, Collegium Medicum, Jagiellonian University, and John Paul II Hospital.
Inclusion: Clinically stable patients (NYHA I-III symptoms) with HF (for at least 6 months) either of ischemic or inflammatory etiology as well as genetic cardiomyopathies; Signed informed consent form; Consent to imaging studies: echocardiography, carotid and transcranial Doppler sonography and neuropsychological tests (MMSE and MoCA).
Exclusion: Previously diagnosed dementia (including severe dementia - MMSE and MoCA score <10); Co-existing, severe, irreversible disease (e.g. advanced cancer); Psychiatric condition which may influence cognitive function; Reversible cause of HF - tachyarrhytmic, peripartum or toxic cardiomyopathy, acute myocarditis, acute myocardial infarction; Cerebral stroke in the preceding 3 months; Anemia with Hemoglobin < 8 g/dl; Acute, decompensated HF; Aortic stenosis; Lack of transcranial Doppler acoustic window; Echocardiographic projections precluding adequate measurements; Alcohol or psychoactive agents abuse.