Frontlight ResearchEarly access
CompletedNo phase
Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure
Key facts
- Who runs it
- The Hospital for Sick Children
- Where
- Canada1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 10 people enrolled
- Started
- 26 Aug 2022
- Ended
- 8 Jan 2024
- Type of study
- Interventional, 2 groups
- Treatments tested
- Esophageal manometry catheter at various PEEP levels and tidal volumes
- Record updated
- 16 July 2025
Who can take part
- Age
- Up to 28 days
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Informed consent provided by parent or primary guardian
- Aged <28 days of life at the time of cardiac surgery
- Undergone surgery using CPB for congenital heart disease
- Undergoing DSC in CCCU
Who cannot take part
- Pre-existing pulmonary disease (For example: Congenital diaphragmatic hernia)
- Pre-existing or new arrhythmia that can impact hemodynamic assessment
- Severe coagulopathy or any other contraindication for the insertion of a nasogastric catheter (e.g., history of tracheo-esophageal fistula)
- Gestational age < 37 weeks or weight < 2 kg at the time of surgery
- Endotracheal tube leak >20%
- Need of extracorporeal support (ECMO), inhaled nitric oxide
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This study aims to describe chest wall mechanics during delayed sternal closure (DSC) in neonates following cardiopulmonary bypass or palliation of congenital heart diseases.
The 2 groups in the trial
- Univentricular physiologyOther group
Neonates with univentricular physiology
Treatment: Esophageal manometry catheter at various PEEP levels and tidal volumes
- Biventricular physiologyOther group
Neonates with biventricular physiology
Treatment: Esophageal manometry catheter at various PEEP levels and tidal volumes
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 16 July 2025