Imaging Brain Repair of Myelin in Children With Multiple Sclerosis
Uses a brain MRI scan to study myelin repair in children with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Exploring Cortical Remyelination in Children With Multiple Sclerosis
Key facts
- Where
- Le Kremlin-Bicêtre and Paris, FranceSee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 18 years old?
Source: NCT05258396, who can take part
Where in France
- Service de Neurologie Pédiatrique, Hôpital du Kremlin BicêtreLe Kremlin-Bicêtre, FranceTaking people
- CIC Neurosciences - Pitié SalpêtrièreParis, FranceTaking people
- Service de Neurologie, GH Pitié SalpêtrièreParis, FranceNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT05258396
- Record updated
- 6 March 2026
- Original description
Multiple sclerosis (MS) in children, a rare disease, follows a relapsing remitting course with a shorter interval between the first 2 clinical events and higher annualized relapse rate as compared with MS in adults. Residual deficits following clinical events are less frequent. The vast majority of children and adolescents with MS are thought to have a greater potential for myelin repair than adults. However convincing data in the literature to support this hypothesis are lacking, because until now no imaging technique has been validated to measure remyelination in vivo.Read full original descriptionShow less
Exploring Cortical Remyelination in Children With Multiple Sclerosis
Multiple sclerosis (MS) in children, a rare disease, follows a relapsing remitting course with a shorter interval between the first 2 clinical events and higher annualized relapse rate as compared with MS in adults. Residual deficits following clinical events are less frequent. The vast majority of children and adolescents with MS are thought to have a greater potential for myelin repair than adults. However convincing data in the literature to support this hypothesis are lacking, because until now no imaging technique has been validated to measure remyelination in vivo.
Inclusion: age between 12 years old and 18 years old; RR-MS defined by 2017 McDonald criteria; no relapse the last 4 weeks; no methylprednisolone or prednisolone the last 4 weeks; affiliated to the social security system; signature of the consent by the 2 holders of parental authority; age between 12 years old and 18 years old; absence of any neurological; signature of the consent by the 2 holders of parental authority.
Exclusion: Parental rejection; Contre-indication of brain MRI: pace maker, tatoo of the face, claustrophobia…; Pregnancy, copper intrauterine device.