Compares two pacing methods for heart failure with right bundle branch block
Compares His-bundle pacing with standard biventricular pacing in adults with heart failure.
Plain-language title generated from the registry record
Registry title: His-Bundle Corrective Pacing in Heart Failure
Key facts
- Where
- Asheville, Burlington, Chicago, Los Angeles, New York, Philadelphia, Phoenix, Richmond, Ridgewood, Tampa, and Wilkes-Barre, United StatesSee the 14 sites
Where in United States
- Mission HealthAsheville, United StatesTaking people
- University of VermontBurlington, United StatesTaking people
- Northwestern Memorial HospitalChicago, United StatesTaking people
- Rush University Medical CenterChicago, United StatesTaking people
- University of ChicagoChicago, United StatesTaking people
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesTaking people
- Weill Cornell Medical CollegeNew York, United StatesTaking people
- University of PennsylvaniaPhiladelphia, United StatesTaking people
- University of ArizonaPhoenix, United StatesTaking people
- Virginia Commonwealth UniversityRichmond, United StatesTaking people
- Valley Health SystemRidgewood, United StatesTaking people
- University of South FloridaTampa, United StatesTaking people
- Geisinger Wyoming ValleyWilkes-Barre, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Rochester
- Trial code
- NCT05265520
- Record updated
- 9 February 2026
- Original description
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).Read full original descriptionShow less
His-Bundle Corrective Pacing in Heart Failure
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).
Inclusion: Age 18 years or older (no upper age limit); Optimal medical therapy for heart failure by current guidelines; Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:; New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR; NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR; NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb).
Exclusion: Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization; On heart transplant list or likely to undergo heart transplant; Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology; Unable or unwilling to follow study protocol; Less than 12 months life expectancy at consent; Pregnancy or planned pregnancy during duration of the study.