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Pathophysiological Endotyping Using Baseline Polysomnography Data

Key facts

Who runs it
University Hospital, Antwerp
Where
Belgium1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
1,000 people, planned
Started
1 Feb 2022
Planned end
Jan 2026
Type of study
Observational
Treatments tested
  • Drug-induced sleep endoscopy
Record updated
13 February 2025

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • 18 years or older
  • Diagnosis with OSA (AHI ≥ 5)
  • Eligible for drug-induced sleep endoscopy as the next step in the clinical path for OSA
  • Capable of giving informed consent

Who cannot take part

  • Medication use related to sleeping disorders
  • Central Sleep Apnea Syndrome
  • Medical history of known causes of tiredness by day or severe sleep disruption (insomnia, PLMS, Narcolepsy)
  • Seizure disorders
  • Known medical history of intellectual disability, memory disorders or current psychiatric disorders (psychotic illness, major depression, or acute anxiety attacks as mentioned by the patient)
  • Diagnostic polysomnography data not available at the Antwerp University Hospital
  • Factors indicative of unstable clinical status or would preclude DISE investigation:
  • Pregnancy or willing to become pregnant

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The study is designed to develop models to predict site of collapse information using routine polysomnography. In an observational study, the investigators will study 1000 patients with obstructive sleep apnea (OSA) who have had a recent polysomnographic study and will undergo drug-induced sleep endoscopy (DISE) as part of their standard clinical care. Flow shape information from the polysomnographic study will be associated with the DISE results, and a set of prediction models will be developed and validated to detect the site, pattern and degree of upper airway collapse as seen during DISE.

The group in the trial

  • Obstructive sleep apnea patients eligible for DISE

    Patients with obstructive sleep apnea (AHI\>=5) will be included in the study. Subjects should be eligible for drug-induced sleep endoscopy as the next step in their clinical path.

    Treatment: Drug-induced sleep endoscopy

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Prediction of Drug-Induced Sleep Endoscopy Outcome From Baseline Diagnostic Data Including Polysomnography
Record updated
13 February 2025