Medical Care Instead of Immediate Heart Pump in Advanced Heart Failure
Studies people with advanced heart failure who are considered for a heart pump.
Key facts
- Who runs it
- Tel-Aviv Sourasky Medical Center
- Where
- Tel Aviv, IsraelSee the site
- Trial code
- Registry title
- Conservative Management of Left Ventricular Assist Device Candidates
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 1 Jan 2018
- Expected to end
- Jan 2028
- Type of study
- Observational
- Record updated
- 8 March 2022
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with advanced heart failure who are being considered for a left ventricular assist device (LVAD, a heart pump). They get intensive medical treatment first.
- Age
- 18 to 80 years
- Sex
- All sexes can join.
- Disease stage
- Advanced heart failure: left ventricular ejection fraction below 35%, New York Heart Association Class III or IV, and a heart failure hospital stay in the past 6 months.
- Earlier treatment
- People must not tolerate conventional heart failure therapy.
- Biomarker or test result
- Brain natriuretic peptide above 450pg/ml and maximal oxygen consumption below 12 ml/kg/min.
Main reasons for not taking part
- Pregnancy
- Unable to give informed consent
- Advanced liver disease (Child Pugh class B or C)
- Advanced kidney disease (eGFR below 30ml/min)
- Severe pulmonary disease, severe peripheral vascular disease or active malignancy
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- left ventricular ejection fraction <35%. New York Heart Association Class III or IV. Brain natriuretic peptide levels > 450pg/ml. Heart failure hospitalization in the past 6 months. Maximal oxygen consumption < 12 ml/kg/min. Intolerant to conventional heart failure therapy
Who cannot take part
- Special populations - pregnant, unable to give informed consent. Advanced liver disease (Child Pugh class B or C). Advanced kidney disease (eGFR<30ml/min). Severe pulmonary disease. Severe peripheral vascular disease. Active malignancy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in Israel
- Tel-Aviv Sourasky Medical CenterTel Aviv, IsraelContact: Ofer Havakuk, MDTaking people
About the trial
What the trial wants to find out
Left ventricular assist device (LVAD) candidates will be comprehensively evaluated at our center, including clinical evaluation, echocardiography, right heart catheterization, cardiopulmonary exercise test and laboratory exams. following this evaluation, patients will be treated with inotropes, diuretics, uptitrated neurohormonal therapy. vitamin and iron deficiencies will be corrected and the patients will be referred for coronary interventions and cardiac resynchronization therapy appropriately. The need for LVAD implantation will be reevaluated according to the patient's clinical condition, echocardiography and laboratory findings.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Conservative Management of Left Ventricular Assist Device Candidates
- Plain-language title
- Medical Care Instead of Immediate Heart Pump in Advanced Heart FailureGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05271214, who can take part
- Record updated
- 8 March 2022