Studies skin and immune cells in people with systemic sclerosis
Collects blood and skin samples from adults with systemic sclerosis to study cells.
Plain-language title generated from the registry record
Registry title: Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis
Key facts
- Where
- Lille, FranceSee the site
Where in France
- Hop Claude Huriez Chu LilleLille, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Lille
- Trial code
- NCT05273138
- Record updated
- 26 December 2025
- Original description
The pathophysiology of systemic sclerosis (SSc) is still poorly understood and there are no effective treatments for this disease. SSc is a heterogeneous disease with varying severity. The heterogeneity of fibroblast profiles, observed in other fibrosing pathologies, has never been thoroughly explored in the skin of SSc patients. The immune system, and in particular B lymphocytes, plays a central role in the pathophysiology of SSc. The interactions between B lymphocytes and the cells responsible for excess collagen production, i.e. fibroblasts, are not fully elucidated The main objective is to analyze the heterogeneity of fibroblasts and infiltrating immune cells as well as their molecular signature in the skin of patients with SScRead full original descriptionShow less
Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis
The pathophysiology of systemic sclerosis (SSc) is still poorly understood and there are no effective treatments for this disease. SSc is a heterogeneous disease with varying severity. The heterogeneity of fibroblast profiles, observed in other fibrosing pathologies, has never been thoroughly explored in the skin of SSc patients. The immune system, and in particular B lymphocytes, plays a central role in the pathophysiology of SSc. The interactions between B lymphocytes and the cells responsible for excess collagen production, i.e. fibroblasts, are not fully elucidated The main objective is to analyze the heterogeneity of fibroblasts and infiltrating immune cells as well as their molecular signature in the skin of patients with SSc
Inclusion: Man or woman over 18 years of age; With a systemic sclerosis meeting the ACR-EULAR 2013 criteria Having signed an informed consent; Being insured.
Exclusion: Dosage of current corticosteroid therapy ≥10mg/d; Syndrome of overlap with another connective tissue disease according to the international diagnostic criteria; Immunosuppressive treatment within 12 months; Protected minors or adults; Pregnant or breastfeeding women; Deprived of their liberty; Persons in emergency situations; Persons who have refused or are unable to give informed consent.