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Studies cell changes in hip osteoarthritis in people having hip replacement surgery

Studies cells in hip joints of adults with hip osteoarthritis undergoing hip replacement surgery.

Key facts

Who runs it
University of Turku
Where
Espoo and Turku, FinlandSee the 4 sites
Trial code
Registry title
Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis
Status
Recruiting
People taking part
110 people, planned
Started
11 Jan 2023
Expected to end
Dec 2028
Type of study
Observational, 3 groups
Treatments tested
  • Total hip arthroplasty
Record updated
24 August 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with hip osteoarthritis having planned hip replacement surgery. It also includes adults without arthritis having emergency hip replacement after an injury, and adults with hip rheumatoid arthritis.

Age
18 to 74 years
Sex
Women and men can join.
Disease stage
Hip osteoarthritis or hip rheumatoid arthritis needing planned total hip replacement; or no arthritis with an emergency hip replacement after trauma.

Main reasons for not taking part

  • Body mass index of 35 or above
  • Under 18 or over 74 years old
  • Diabetes (osteoarthritis group)
  • Rheumatoid arthritis or metabolic syndrome (osteoarthritis group)

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty
  • Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty
  • ----
  • Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty
  • ----

Who cannot take part

  • The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome; For the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA
  • Age < 18 or > 74
  • The body mass index must be below 35

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 74 years old?

Where in Finland

  • Helsinki University HospitalEspoo, FinlandContact: Anna Vasara, MD, PhDTaking people
  • Turku University HospitalTurku, FinlandContact: Pjotr Sarantsin, MDTaking people
  • PET-centre, University of TurkuTurku, FinlandContact: Lea Mikkola, PhDNo longer taking part
  • Turku Bioscience, University of TurkuTurku, FinlandContact: Lea Mikkola, PhDNo longer taking part

About the trial

What the trial wants to find out

The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.

The 3 groups in the trial

  • OA cases

    Fifty adult patients who have hip osteoarthritis.

    Treatment: Total hip arthroplasty

  • RA cases

    Forty adult patients who have rheumatoid arthritis in the hip joint.

    Treatment: Total hip arthroplasty

  • Non-arthritic controls

    Twenty adult patients who go through trauma-based emergency total hip arthroplasty and do not have arthritis.

    Treatment: Total hip arthroplasty

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Studies on the Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis
Plain-language title
Studies cell changes in hip osteoarthritis in people having hip replacement surgeryGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT05278520, who can take part
Record updated
24 August 2025