Early Heart Rhythm Treatment After Stroke in Atrial Fibrillation Patients
Tests early rhythm control therapy in adults with stroke and atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
Key facts
- Where
- Bad Neustadt A.D.Saale, Berlin, Bielefeld, Bonn, Cologne, Dresden, Erlangen, Essen, Frankfurt Am Main, Giessen, Halle (Saale), Hamburg, Hanover, Heidelberg, Kiel, Leipzig, Luebeck, Lueneburg, Mannheim, Marburg, Muenster, Munich, Neumuenster, Tuebingen, Ulm, and Wuerzburg, GermanySee the 29 sites
- Phase
- Phase 3
Where in Germany
- Rhoen-Klinikum AGBad Neustadt A.D.Saale, GermanyTaking people
- Charite Universitaetsmedizin Berlin KöRBerlin, GermanyTaking people
- Vivantes Netzwerk fuer Gesundheit GmbHBerlin, GermanyTaking people
- Evangelisches Klinikum Bethel gGmbHBielefeld, GermanyTaking people
- Universitaetsklinikum Bonn AöRBonn, GermanyTaking people
- University Hospital Cologne AöRCologne, GermanyTaking people
- Technische Universitaet DresdenDresden, GermanyTaking people
- Universitaetsklinikum Erlangen AöRErlangen, GermanyTaking people
- Universitaetsklinikum Essen (AoR)Essen, GermanyTaking people
- Goethe University FrankfurtFrankfurt Am Main, GermanyTaking people
- Klinikum Frankfurt Hoechst GmbHFrankfurt Am Main, GermanyTaking people
- Justus-Liebig-Universitaet GiessenGiessen, GermanyTaking people
- BG Klinikum Bergmannstrost Halle gGmbHHalle (Saale), GermanyTaking people
- University Medical Center Hamburg-EppendorfHamburg, GermanyTaking people
- Medizinische Hochschule HannoverHanover, GermanyTaking people
- Universitaetsklinikum Heidelberg AöRHeidelberg, GermanyTaking people
- Universitaetsklinikum Schleswig-Holstein AöRKiel, GermanyTaking people
- Universitaet LeipzigLeipzig, GermanyTaking people
- Universitaetsklinikum Schleswig-Holstein AöRLuebeck, GermanyTaking people
- Staedtisches Klinikum Lueneburg gGmbHLueneburg, GermanyTaking people
- Heidelberg UniversityMannheim, GermanyTaking people
- Philipps-Universitaet MarburgMarburg, GermanyTaking people
- Universitaet MuensterMuenster, GermanyTaking people
- Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)Munich, GermanyTaking people
- LMU Klinikum Muenchen AöRMunich, GermanyTaking people
- FEK Friedrich-Ebert-Krankenhaus Neumuenster GmbHNeumuenster, GermanyTaking people
- Universitaetsklinikum Tuebingen AöRTuebingen, GermanyTaking people
- Universitaetsklinikum Ulm AoRUlm, GermanyTaking people
- Universitaetsklinikum Wuerzburg AöRWuerzburg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universitätsklinikum Hamburg-Eppendorf
- Trial code
- NCT05293080EU 2025-521260-35-00
- Record updated
- 18 May 2026
- Original description
This study will determine whether early, comprehensive, rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care.Read full original descriptionShow less
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study will determine whether early, comprehensive, rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care.
Inclusion: Acute ischemic stroke in the previous four weeks, diagnosed by imaging (CT or MRI) or clinical diagnosis; Possibility to start the trial treatment within 4 weeks after stroke, and as soon as clinically justifiable; AF first detected ≤1 year prior to randomization; Informed consent.
Exclusion: Prior AF ablation or surgical therapy of AF; End-stage cancer or life-expectancy < 12 months due to other advanced co-morbid illness; Patients not suitable for rhythm control of AF due to cardiac conditions.