Comparing immune signals in psoriasis with and without joint involvement
Compares immune messengers in blood and skin of adults with psoriasis and joint disease.
Plain-language title generated from the registry record
Registry title: Cytokine Expression in Psoriasis Patients With and Without Joint Involvement
Key facts
- Where
- Poitiers, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT05307809, who can take part
Where in France
- CHU PoitiersPoitiers, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Poitiers University Hospital
- Trial code
- NCT05307809
- Record updated
- 31 August 2026
- Original description
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.Read full original descriptionShow less
Cytokine Expression in Sera, ex Vivo Stimulated Peripheral Blood Mononuclear Cells Culture, and Skin in Psoriasis - Comparison of Patients With and Without Joint Involvement
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.
Inclusion: For psoriasis patients :; Age over 18 years old; Signed informed consent; 5 year old psoriasis at least; At least one skin lesion over 2 cm; Without any articular symptoms; Without any DMARDs; Without anticoagulant treatments or coagulation disease; With normal articular and enthesis sonography; For psoriatic arthritis patients :; Age over 18 years old; Signed informed consent; Psoriatic arthritis according to CASPAR criteria; Without any DMARDs; Without anticoagulant treatments or coagulation disease; With at least one synovitis at inclusion; For controls; Age and sex matched with a patient without any rheumatic or dermatologic medical conditions; No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old.
Exclusion: People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients; ▪ For psoriasis patients :; Joint damage according to CASPAR criteria; Echography activity in favor of chronic inflammatory rheumatism; For patients and controls:; Without social protection rights.