Optimizing Cerebral Autoregulation During Surgery
Key facts
- Who runs it
- Johns Hopkins University
- Where
- Baltimore, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 27 people enrolled
- Started
- 9 Jan 2023
- Ended
- 30 Jul 2025
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Blood pressure management according to cerebral autoregulation
- Blood pressure management according to usual care
- Record updated
- 2 September 2025
Who can take part
- Age
- 60 years to 100 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- planned hip or knee surgery (either for fracture or elective) or lung surgery
- age ≥60
- ambulatory at baseline
- expected duration of surgery > 90 minutes
Who cannot take part
- Planned concurrent surgery
- Allergy to adhesive tape
- Clinical diagnosis of dementia
- Short Blessed Test score >20
- Opinion of either the anesthesiologist or surgeon that the patient is not appropriate
Where in United States
- The Johns Hopkins UniversityBaltimore, United States
About the trial
What the trial wants to find out
The purpose of this study is to conduct a pilot trial to determine the feasibility, safety, and potential efficacy of targeting mean arterial blood pressure (MAP) within the limits of cerebral autoregulation during surgery compared with usual care.
The 2 groups in the trial
- Blood pressure managed by cerebral autoregulationTreatment being tested
In this arm cerebral autoregulation monitoring will be used to determine the lower and upper limits of cerebral autoregulation. Monitoring will continue throughout the surgery. Blood pressure management will be maintained to be within the limits of cerebral autoregulation.
Treatment: Blood pressure management according to cerebral autoregulation
- Standard of care blood pressure managementExisting treatment, for comparison
In this arm cerebral autoregulation monitoring will be used for observation. The anesthesia provider will use usual care guidelines for blood pressure management.
Treatment: Blood pressure management according to usual care
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 2 September 2025