Tests dichloroacetate effects on brain sugar use in type 1 diabetes
Tests dichloroacetate in adults with type 1 diabetes and low blood sugar awareness.
Plain-language title generated from the registry record
Registry title: Regulation of Brain Glucose Metabolism in Type 1 Diabetes
Key facts
- Where
- New Haven, United StatesSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Source: NCT05317455, who can take part
Where in United States
- Yale New Haven HospitalNew Haven, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Yale University
- Trial code
- NCT05317455
- Record updated
- 9 June 2026
- Original description
This is a prospective randomized placebo-controlled double-blind crossover pilot study determining the effect of dichloroacetate on brain function under clamped hypoglycemia in T1DM.Read full original descriptionShow less
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
This is a prospective randomized placebo-controlled double-blind crossover pilot study determining the effect of dichloroacetate on brain function under clamped hypoglycemia in T1DM.
Inclusion: T1DM subjects with:; a history of severe hypoglycemia and/or hypoglycemia unawareness or; a history of severe hypoglycemia with a blood glucose <54 mg/dL, requiring the assistance of another person (with recovery after the administration of oral carbohydrate, intravenous glucose, or glucagon) or; at least 2 values <54mg/dl during 2 weeks of CGMS testing during the week prior to study.
Exclusion: Age < 18 years or >55 years; Body weight >85 kg at screening visit; BMI > 30 (female) and >30 (male) kg/m2; Untreated proliferative retinopathy; carriers of glutathione transferase Z1 (GSTZ-1) gene polymorphisms that predispose to DCA accumulation and toxicity.