Adds precise radiation to immune therapy for advanced kidney cancer
Tests adding focused radiation to standard immunotherapy in adults with advanced kidney cancer.
Plain-language title generated from the registry record
Registry title: Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
Key facts
- Where
- Albuquerque, Alexandria, Allentown, Alton, Ames, Ankeny, Ann Arbor, Antigo, Arroyo Grande, Ashland, Aurora, Aventura, Avon, Baltimore, Basking Ridge, Bath, Baton Rouge, Bay Shore, Beachwood, Beaver, Bellevue, Bemidji, Berlin Corners, Bethlehem, Beverly, Beverly Hills, Biddeford, Birmingham, Bismarck, Boise, Boston, Brainerd, Brighton, Burlingame, Burlington, Caldwell, Camden, Canton, Cape Girardeau, Carlisle, Cary, Centerville, Centralia, Chadds Ford, Chapel Hill, Charleston, Charlotte, Chaska, Chelsea, Chicago, Cincinnati, City of Saint Peters, Clemmons, Cleveland, Clive, Columbia, Columbus, Commack, Concord, Coon Rapids, Creve Coeur, Crown Point, Dallas, Danville, Dayton, Dearborn, Decatur, Deer River, DeKalb, Denver, Des Moines, Dickson City, Duarte, Duluth, Durham, Eau Claire, Edina, Effingham, Encinitas, Erie, Fairfax, Fargo, Farmington Hills, Farrell, Fayetteville, Fort Collins, Fort Worth, Franklin, Gastonia, Geneva, Glen Burnie, Glens Falls, Glenview, Gloucester, Grayslake, Greeley, Green Bay, Greenlawn, Greensburg, Greenville, Greenwood, Harrisburg, Harrison, Harvey, Hayward, Hazleton, Hershey, Hibbing, High Point, Highlands Ranch, Hollywood, Huntington, Indiana, Indianapolis, Irvine, Jacksonville, Jefferson Hills, Kingman, La Crosse, La Jolla, Ladysmith, Lake Forest, Lake Success, Lakewood, Land O' Lakes, Lansing, Lewes, Lewisburg, Little Rock, Livonia, Lone Tree, Long Branch, Los Angeles, Loveland, Madison, Maple Grove, Marshfield, Mattoon, Mechanicsburg, Menomonee Falls, Mentor, Metairie, Miami, Miami Beach, Middletown, Midlothian, Millville, Milwaukee, Minneapolis, Minocqua, Modesto, Monroe, Monroeville, Montvale, Mooresville, Mount Kisco, Mount Laurel, Mukwonago, Nampa, Neillsville, New Brunswick, New Castle, New Lenox, New Orleans, New Richmond, New York, Newark, O'Fallon, Oak Brook, Oak Creek, Oconomowoc, Oklahoma City, Omaha, Orange, Orland Park, Parma, Peabody, Pembroke Pines, Phoenix, Pittsburgh, Portland, Pottsville, Raleigh, Ravenna, Rehoboth Beach, Reno, Rhinelander, Rice Lake, Richardson, Richmond, Rochester, Rockford, Rogers, Roseville, Royal Oak, Ruskin, Sacramento, Saint Louis Park, Saint Paul, San Diego, San Francisco, San Luis Obispo, San Mateo, Sandstone, Sanford, Santa Barbara, Santa Rosa, Scarborough, Scranton, Seattle, Seneca, Shakopee, Sheboygan, Shiloh, Sioux Falls, Sleepy Hollow, South Portland, Spooner, Springdale, Springfield, St Louis, Statesville, Stevens Point, Stillwater, Stony Brook, Sturgeon Bay, Superior, Tampa, Temple, Toms River, Troy, Tulsa, Uniondale, Urbana, Virginia, Waconia, Warrenville, Washington, Waukee, Waukesha, Wausau, Wesley Chapel, West Bend, West Chester, West Reading, Weston, Wexford, Wilkes-Barre, Wilkesboro, Williamsport, Wilmington, Winchester, Winston-Salem, Wisconsin Rapids, York, and Ypsilanti, United StatesSee the 342 sites
- Phase
- Phase 2
Where in United States
- Lovelace Medical Center-Saint Joseph SquareAlbuquerque, United StatesTaking people
- Lovelace Radiation OncologyAlbuquerque, United StatesTaking people
- University of New Mexico Cancer CenterAlbuquerque, United StatesTaking people
- Inova Alexandria HospitalAlexandria, United StatesTaking people
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
- Alton Memorial HospitalAlton, United StatesTaking people
- Mary Greeley Medical CenterAmes, United StatesTaking people
- McFarland Clinic - AmesAmes, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, United StatesTaking people
- University of Michigan Rogel Cancer CenterAnn Arbor, United StatesTaking people
- Aspirus Cancer Care-Antigo-Volm Cancer CenterAntigo, United StatesTaking people
- PCR OncologyArroyo Grande, United StatesNo longer taking part
- Duluth Clinic AshlandAshland, United StatesTaking people
- Northwest Wisconsin Cancer CenterAshland, United StatesTaking people
- UCHealth University of Colorado HospitalAurora, United StatesTaking people
- Mount Sinai Comprehensive Cancer Center at AventuraAventura, United StatesTaking people
- UH Seidman Cancer Center at UH Avon Health CenterAvon, United StatesTaking people
- University of Maryland/Greenebaum Cancer CenterBaltimore, United StatesNo longer taking part
- Memorial Sloan Kettering Basking RidgeBasking Ridge, United StatesTaking people
- MaineHealth Coastal Cancer Treatment CenterBath, United StatesNo longer taking part
- Louisiana Hematology Oncology Associates LLCBaton Rouge, United StatesTaking people
- Mary Bird Perkins Cancer CenterBaton Rouge, United StatesTaking people
- Northwell Health Imbert Cancer CenterBay Shore, United StatesTaking people
- UHHS-Chagrin Highlands Medical CenterBeachwood, United StatesTaking people
- UPMC-Heritage Valley Health System BeaverBeaver, United StatesTaking people
- Nebraska Medicine-BellevueBellevue, United StatesTaking people
- Sanford Joe Lueken Cancer CenterBemidji, United StatesTaking people
- Central Vermont Medical Center/National Life Cancer TreatmentBerlin Corners, United StatesTaking people
- Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesTaking people
- Beverly HospitalBeverly, United StatesNo longer taking part
- Tower Cancer Research FoundationBeverly Hills, United StatesTaking people
- MaineHealth Maine Medical Center - BiddefordBiddeford, United StatesNo longer taking part
- University of Alabama at Birmingham Cancer CenterBirmingham, United StatesNo longer taking part
- Sanford Bismarck Medical CenterBismarck, United StatesTaking people
- Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesTaking people
- Brigham and Women's HospitalBoston, United StatesTaking people
- Dana-Farber Cancer InstituteBoston, United StatesTaking people
- Massachusetts General Hospital Cancer CenterBoston, United StatesTaking people
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
- Trinity Health Medical Center - BrightonBrighton, United StatesTaking people
- Mills-Peninsula Medical CenterBurlingame, United StatesTaking people
- University of Vermont and State Agricultural CollegeBurlington, United StatesTaking people
- University of Vermont Medical CenterBurlington, United StatesTaking people
- Lahey ClinicBurlington, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesTaking people
- Cooper Hospital University Medical CenterCamden, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
- Trinity Health Medical Center - CantonCanton, United StatesTaking people
- Saint Francis Medical CenterCape Girardeau, United StatesTaking people
- Carlisle Regional Cancer CenterCarlisle, United StatesTaking people
- Duke Cancer Center CaryCary, United StatesTaking people
- Miami Valley Hospital SouthCenterville, United StatesTaking people
- Dayton Physicians LLC-Miami Valley SouthCenterville, United StatesNo longer taking part
- Centralia Oncology ClinicCentralia, United StatesTaking people
- Christiana Care Health System-Concord Health CenterChadds Ford, United StatesTaking people
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Vandalia Health/CAMC Institute for Academic MedicineCharleston, United StatesNo longer taking part
- Atrium Health Pineville/LCI-PinevilleCharlotte, United StatesTaking people
- Atrium Health University City/LCI-UniversityCharlotte, United StatesTaking people
- Carolinas Medical Center/Levine Cancer InstituteCharlotte, United StatesTaking people
- Levine Cancer Institute-BallantyneCharlotte, United StatesTaking people
- Minnesota Oncology Hematology PA-ChaskaChaska, United StatesTaking people
- Chelsea HospitalChelsea, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
- Northwestern Medicine Cancer Center Old Irving ParkChicago, United StatesTaking people
- Northwestern UniversityChicago, United StatesTaking people
- University of Chicago Comprehensive Cancer CenterChicago, United StatesTaking people
- University of Cincinnati Cancer Center-UC Medical CenterCincinnati, United StatesTaking people
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, United StatesTaking people
- Wake Forest University at ClemmonsClemmons, United StatesTaking people
- Case Western Reserve UniversityCleveland, United StatesTaking people
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
- MU Health - University Hospital/Ellis Fischel Cancer CenterColumbia, United StatesTaking people
- Central Maryland Radiation Oncology in Howard CountyColumbia, United StatesNo longer taking part
- Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
- Memorial Sloan Kettering CommackCommack, United StatesTaking people
- Atrium Health Cabarrus/LCI-ConcordConcord, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- Siteman Cancer Center at West County HospitalCreve Coeur, United StatesTaking people
- UChicago Medicine Northwest IndianaCrown Point, United StatesTaking people
- Parkland Memorial HospitalDallas, United StatesTaking people
- UT Southwestern Simmons Cancer Center - RedBirdDallas, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesTaking people
- Carle at The RiverfrontDanville, United StatesTaking people
- Geisinger Medical CenterDanville, United StatesTaking people
- Miami Valley HospitalDayton, United StatesTaking people
- Miami Valley Hospital NorthDayton, United StatesTaking people
- Premier Blood and Cancer CenterDayton, United StatesTaking people
- Dayton Physician LLC - EnglewoodDayton, United StatesNo longer taking part
- Corewell Health Dearborn HospitalDearborn, United StatesTaking people
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Decatur Memorial HospitalDecatur, United StatesTaking people
- Essentia Health - Deer River ClinicDeer River, United StatesTaking people
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesTaking people
- UCHealth - Cherry CreekDenver, United StatesTaking people
- Iowa Methodist Medical CenterDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
- Geisinger Cancer Center Dickson CityDickson City, United StatesTaking people
- City of Hope Comprehensive Cancer CenterDuarte, United StatesNo longer taking part
- Essentia Health Cancer CenterDuluth, United StatesTaking people
- Essentia Health Saint Mary's Medical CenterDuluth, United StatesTaking people
- Miller-Dwan HospitalDuluth, United StatesTaking people
- Duke University Medical CenterDurham, United StatesTaking people
- Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
- Fairview Southdale HospitalEdina, United StatesTaking people
- Carle Physician Group-EffinghamEffingham, United StatesTaking people
- Crossroads Cancer CenterEffingham, United StatesTaking people
- UC San Diego Health System - EncinitasEncinitas, United StatesTaking people
- Saint Vincent HospitalErie, United StatesTaking people
- UPMC Hillman Cancer Center ErieErie, United StatesTaking people
- Inova Fair Oaks HospitalFairfax, United StatesTaking people
- Inova Schar Cancer InstituteFairfax, United StatesTaking people
- Sanford Broadway Medical CenterFargo, United StatesTaking people
- Sanford Roger Maris Cancer CenterFargo, United StatesTaking people
- Corewell Health Farmington Hills HospitalFarmington Hills, United StatesNo longer taking part
- UPMC Cancer Center at UPMC HorizonFarrell, United StatesTaking people
- Highlands Oncology Group - FayettevilleFayetteville, United StatesTaking people
- Cancer Care and Hematology-Fort CollinsFort Collins, United StatesTaking people
- Poudre Valley HospitalFort Collins, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-Fort WorthFort Worth, United StatesTaking people
- Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesTaking people
- Dayton Physicians LLC-AtriumFranklin, United StatesNo longer taking part
- Levine Cancer Institute-GastonGastonia, United StatesTaking people
- Northwestern Medicine Cancer Center DelnorGeneva, United StatesTaking people
- UM Baltimore Washington Medical Center/Tate Cancer CenterGlen Burnie, United StatesNo longer taking part
- Glens Falls HospitalGlens Falls, United StatesTaking people
- Northwestern Medicine Glenview Outpatient CenterGlenview, United StatesTaking people
- Addison Gilbert HospitalGloucester, United StatesNo longer taking part
- Northwestern Medicine Grayslake Outpatient CenterGrayslake, United StatesTaking people
- UCHealth Greeley HospitalGreeley, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesTaking people
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesTaking people
- Northwell Health Cancer Institute at HuntingtonGreenlawn, United StatesTaking people
- UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, United StatesTaking people
- Miami Valley Cancer Care and InfusionGreenville, United StatesTaking people
- Self Regional HealthcareGreenwood, United StatesTaking people
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, United StatesTaking people
- Memorial Sloan Kettering WestchesterHarrison, United StatesTaking people
- Ingalls Memorial HospitalHarvey, United StatesTaking people
- Essentia Health-Hayward ClinicHayward, United StatesTaking people
- Geisinger Medical Center-Cancer Center HazletonHazleton, United StatesTaking people
- Penn State Milton S. Hershey Medical CenterHershey, United StatesTaking people
- Essentia Health Hibbing ClinicHibbing, United StatesTaking people
- Hayworth Cancer CenterHigh Point, United StatesTaking people
- UCHealth Highlands Ranch HospitalHighlands Ranch, United StatesTaking people
- Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, United StatesTaking people
- Edwards Comprehensive Cancer CenterHuntington, United StatesTaking people
- IRMC Cancer CenterIndiana, United StatesTaking people
- Franciscan Health IndianapolisIndianapolis, United StatesTaking people
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, United StatesTaking people
- Mayo Clinic in FloridaJacksonville, United StatesTaking people
- Jefferson HospitalJefferson Hills, United StatesTaking people
- Kingman Regional Medical CenterKingman, United StatesNo longer taking part
- Gundersen Lutheran Medical CenterLa Crosse, United StatesTaking people
- UC San Diego Moores Cancer CenterLa Jolla, United StatesTaking people
- Marshfield Medical Center - LadysmithLadysmith, United StatesNo longer taking part
- Northwestern Medicine Lake Forest HospitalLake Forest, United StatesTaking people
- Northwell Health/Center for Advanced MedicineLake Success, United StatesTaking people
- Monmouth Medical Center Southern CampusLakewood, United StatesNo longer taking part
- Moffitt Cancer Center at SperosLand O' Lakes, United StatesTaking people
- University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
- Beebe Medical CenterLewes, United StatesTaking people
- Geisinger Medical Oncology-LewisburgLewisburg, United StatesTaking people
- University of Arkansas for Medical SciencesLittle Rock, United StatesTaking people
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- UCHealth Lone Tree Health CenterLone Tree, United StatesTaking people
- Monmouth Medical CenterLong Branch, United StatesNo longer taking part
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Los Angeles General Medical CenterLos Angeles, United StatesTaking people
- The Angeles Clinic and Research Institute - West Los Angeles OfficeLos Angeles, United StatesTaking people
- USC / Norris Comprehensive Cancer CenterLos Angeles, United StatesTaking people
- Medical Center of the RockiesLoveland, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, United StatesTaking people
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, United StatesTaking people
- Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, United StatesTaking people
- Froedtert Menomonee Falls HospitalMenomonee Falls, United StatesTaking people
- UH Seidman Cancer Center at Lake Health Mentor CampusMentor, United StatesTaking people
- Mary Bird Perkins Cancer Center - MetairieMetairie, United StatesTaking people
- East Jefferson General HospitalMetairie, United StatesNo longer taking part
- LSU Healthcare Network / Metairie Multi-Specialty ClinicMetairie, United StatesNo longer taking part
- Miami Cancer InstituteMiami, United StatesTaking people
- Mount Sinai Medical CenterMiami Beach, United StatesTaking people
- Memorial Sloan Kettering MonmouthMiddletown, United StatesTaking people
- Bon Secours Saint Francis Medical CenterMidlothian, United StatesTaking people
- Beebe South Coastal Health CampusMillville, United StatesTaking people
- Medical College of WisconsinMilwaukee, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
- Hennepin County Medical CenterMinneapolis, United StatesTaking people
- University of Minnesota/Masonic Cancer CenterMinneapolis, United StatesTaking people
- Marshfield Medical Center - MinocquaMinocqua, United StatesTaking people
- Memorial Medical CenterModesto, United StatesTaking people
- Atrium Health Union/LCI-UnionMonroe, United StatesTaking people
- Forbes HospitalMonroeville, United StatesTaking people
- UPMC Cancer Center - MonroevilleMonroeville, United StatesTaking people
- UPMC Hillman Cancer Center - MonroevilleMonroeville, United StatesTaking people
- Memorial Sloan Kettering BergenMontvale, United StatesTaking people
- Franciscan Health MooresvilleMooresville, United StatesTaking people
- Northern Westchester HospitalMount Kisco, United StatesTaking people
- Cooper CyberKnife CenterMount Laurel, United StatesTaking people
- ProHealth D N Greenwald CenterMukwonago, United StatesTaking people
- Saint Alphonsus Cancer Care Center-NampaNampa, United StatesTaking people
- Marshfield Medical Center - NeillsvilleNeillsville, United StatesNo longer taking part
- Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesNo longer taking part
- UPMC Hillman Cancer Center - New CastleNew Castle, United StatesTaking people
- UC Comprehensive Cancer Center at Silver CrossNew Lenox, United StatesTaking people
- Louisiana State University Health Science CenterNew Orleans, United StatesNo longer taking part
- Touro InfirmaryNew Orleans, United StatesNo longer taking part
- University Medical Center New OrleansNew Orleans, United StatesNo longer taking part
- Cancer Center of Western WisconsinNew Richmond, United StatesTaking people
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, United StatesTaking people
- Lenox Hill HospitalNew York, United StatesTaking people
- Manhattan Eye Ear and Throat HospitalNew York, United StatesTaking people
- Memorial Sloan-Kettering Cancer CenterNew York, United StatesTaking people
- Christiana Care Health System-Christiana HospitalNewark, United StatesTaking people
- Helen F Graham Cancer CenterNewark, United StatesTaking people
- Medical Oncology Hematology Consultants PANewark, United StatesTaking people
- Rutgers New Jersey Medical SchoolNewark, United StatesNo longer taking part
- Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
- HSHS Saint Elizabeth's HospitalO'Fallon, United StatesTaking people
- Northwestern Medicine Oak BrookOak Brook, United StatesTaking people
- Drexel Town Square Health CenterOak Creek, United StatesTaking people
- ProHealth Oconomowoc Memorial HospitalOconomowoc, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Nebraska Medicine-Village PointeOmaha, United StatesTaking people
- University of Nebraska Medical CenterOmaha, United StatesTaking people
- UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, United StatesTaking people
- Northwestern Medicine Orland ParkOrland Park, United StatesTaking people
- University of Chicago Medicine-Orland ParkOrland Park, United StatesTaking people
- University Hospitals Parma Medical CenterParma, United StatesTaking people
- Lahey Clinic PeabodyPeabody, United StatesNo longer taking part
- Memorial Hospital WestPembroke Pines, United StatesTaking people
- Mayo Clinic Hospital in ArizonaPhoenix, United StatesTaking people
- Allegheny General HospitalPittsburgh, United StatesTaking people
- UPMC Hillman Cancer CenterPittsburgh, United StatesTaking people
- UPMC-Magee Womens HospitalPittsburgh, United StatesTaking people
- UPMC-Passavant HospitalPittsburgh, United StatesTaking people
- UPMC-Saint Clair Hospital Cancer CenterPittsburgh, United StatesTaking people
- UPMC-Saint MargaretPittsburgh, United StatesTaking people
- UPMC-Shadyside HospitalPittsburgh, United StatesTaking people
- West Penn HospitalPittsburgh, United StatesTaking people
- MaineHealth Maine Medical Center - PortlandPortland, United StatesNo longer taking part
- Geisinger Cancer Services-PottsvillePottsville, United StatesTaking people
- Duke Cancer Center RaleighRaleigh, United StatesTaking people
- University Hospitals Portage Medical CenterRavenna, United StatesTaking people
- Beebe Health CampusRehoboth Beach, United StatesTaking people
- Renown Regional Medical CenterReno, United StatesTaking people
- Aspirus Cancer Care-Rhinelander-James Beck Cancer CenterRhinelander, United StatesTaking people
- Marshfield Medical Center-Rice LakeRice Lake, United StatesTaking people
- UT Southwestern Clinical Center at Richardson/PlanoRichardson, United StatesTaking people
- Bon Secours Cancer Institute at Reynolds CrossingRichmond, United StatesTaking people
- VCU Massey Cancer Center at Stony PointRichmond, United StatesTaking people
- VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
- Mayo Clinic in RochesterRochester, United StatesTaking people
- UW Health Carbone Cancer Center RockfordRockford, United StatesTaking people
- Highlands Oncology Group - RogersRogers, United StatesTaking people
- Sutter Cancer Centers Radiation Oncology Services-RosevilleRoseville, United StatesTaking people
- Sutter Roseville Medical CenterRoseville, United StatesTaking people
- Corewell Health William Beaumont University HospitalRoyal Oak, United StatesTaking people
- Moffitt Cancer Center at SouthShoreRuskin, United StatesTaking people
- Sutter Medical Center SacramentoSacramento, United StatesTaking people
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- UC San Diego Medical Center - HillcrestSan Diego, United StatesTaking people
- UCSF Medical Center-Mission BaySan Francisco, United StatesTaking people
- Pacific Central Coast Health Center-San Luis ObispoSan Luis Obispo, United StatesNo longer taking part
- Mills Health CenterSan Mateo, United StatesTaking people
- Essentia Health SandstoneSandstone, United StatesTaking people
- MaineHealth Cancer Care and IV Therapy - SanfordSanford, United StatesNo longer taking part
- MaineHealth Cancer Care Center of York CountySanford, United StatesNo longer taking part
- Ridley-Tree Cancer CenterSanta Barbara, United StatesTaking people
- Sutter Pacific Medical FoundationSanta Rosa, United StatesTaking people
- MaineHealth Maine Medical Center- ScarboroughScarborough, United StatesNo longer taking part
- Community Medical CenterScranton, United StatesTaking people
- Virginia Mason Medical CenterSeattle, United StatesTaking people
- UPMC Cancer Center at UPMC NorthwestSeneca, United StatesTaking people
- Saint Francis Regional Medical CenterShakopee, United StatesTaking people
- Saint Vincent Hospital Cancer Center at SheboyganSheboygan, United StatesTaking people
- Memorial Hospital EastShiloh, United StatesTaking people
- Sanford Cancer Center Oncology ClinicSioux Falls, United StatesTaking people
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesTaking people
- Phelps Memorial Hospital CenterSleepy Hollow, United StatesTaking people
- MaineHealth Cancer Care and IV Therapy - South PortlandSouth Portland, United StatesNo longer taking part
- Essentia Health-Spooner ClinicSpooner, United StatesTaking people
- Highlands Oncology GroupSpringdale, United StatesTaking people
- Mercy Hospital SpringfieldSpringfield, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- Springfield Memorial HospitalSpringfield, United StatesTaking people
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Mercy Hospital SouthSt Louis, United StatesTaking people
- Siteman Cancer Center at Christian HospitalSt Louis, United StatesTaking people
- Siteman Cancer Center-South CountySt Louis, United StatesTaking people
- Washington University School of MedicineSt Louis, United StatesTaking people
- Wake Forest Baptist Health - Hematology Oncology - StatesvilleStatesville, United StatesTaking people
- Aspirus Cancer Care - Stevens PointStevens Point, United StatesTaking people
- Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
- Lakeview HospitalStillwater, United StatesTaking people
- Stony Brook University Medical CenterStony Brook, United StatesNo longer taking part
- Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, United StatesTaking people
- Essentia Health Saint Mary's Hospital - SuperiorSuperior, United StatesTaking people
- Moffitt Cancer CenterTampa, United StatesTaking people
- Moffitt Cancer Center - McKinley CampusTampa, United StatesTaking people
- Moffitt Cancer Center-International PlazaTampa, United StatesTaking people
- Scott and White Memorial HospitalTemple, United StatesTaking people
- Community Medical CenterToms River, United StatesNo longer taking part
- Corewell Health Beaumont Troy HospitalTroy, United StatesTaking people
- Upper Valley Medical CenterTroy, United StatesTaking people
- Oklahoma Cancer Specialists and Research Institute-TulsaTulsa, United StatesTaking people
- Memorial Sloan Kettering NassauUniondale, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- The Carle Foundation HospitalUrbana, United StatesTaking people
- Essentia Health Virginia ClinicVirginia, United StatesTaking people
- Ridgeview Medical CenterWaconia, United StatesTaking people
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesTaking people
- UPMC Cancer Center-WashingtonWashington, United StatesTaking people
- UPMC Washington Hospital Radiation OncologyWashington, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, United StatesTaking people
- UW Cancer Center at ProHealth CareWaukesha, United StatesTaking people
- Aspirus Cancer Care-WausauWausau, United StatesTaking people
- Moffitt Cancer Center at Wesley ChapelWesley Chapel, United StatesTaking people
- Froedtert West Bend Hospital/Kraemer Cancer CenterWest Bend, United StatesTaking people
- University of Cincinnati Cancer Center-West ChesterWest Chester, United StatesTaking people
- Reading HospitalWest Reading, United StatesTaking people
- Marshfield Medical Center - WestonWeston, United StatesTaking people
- Wexford Health and Wellness PavilionWexford, United StatesTaking people
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, United StatesTaking people
- Wake Forest Baptist Health - Wilkes Medical CenterWilkesboro, United StatesTaking people
- Divine Providence HospitalWilliamsport, United StatesTaking people
- Christiana Care Health System-Wilmington HospitalWilmington, United StatesTaking people
- Beth Israel Deaconess Medical Center/Winchester Center for Cancer CareWinchester, United StatesNo longer taking part
- Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
- Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, United StatesTaking people
- Marshfield Clinic - Wisconsin Rapids CenterWisconsin Rapids, United StatesNo longer taking part
- UPMC MemorialYork, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- NRG Oncology
- Trial code
- NCT05327686
- Record updated
- 23 October 2026
- Original description
This phase II trial tests whether the addition of radiation to the primary tumor, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell cancer that is not recommended for surgery and has spread from where it first started (primary site) to other places in the body (metastatic). Radiation therapy uses high energy photons to kill tumor cells and shrink tumors. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses of radiation over a shorter period and cause less damage to normal tissue. Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, avelumab, and pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Axitinib, cabozantinib, and lenvatinib are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving SABR in combination with standard of care immunotherapy may help shrink or stabilize the cancer in patients with renal cell cancer.Read full original descriptionShow less
Randomized Phase II Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Unresected Renal Cell Carcinoma (RCC) Receiving Immunotherapy (SAMURAI)
This phase II trial tests whether the addition of radiation to the primary tumor, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell cancer that is not recommended for surgery and has spread from where it first started (primary site) to other places in the body (metastatic). Radiation therapy uses high energy photons to kill tumor cells and shrink tumors. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses of radiation over a shorter period and cause less damage to normal tissue. Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, avelumab, and pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Axitinib, cabozantinib, and lenvatinib are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving SABR in combination with standard of care immunotherapy may help shrink or stabilize the cancer in patients with renal cell cancer.
Inclusion: Pathologically (histologically or cytologically) proven diagnosis of renal cell carcinoma prior to registration; Node-positive unresectable (TxN1Mx) or metastatic (TxNxM1) based on the following diagnostic workup:; History/physical examination within 45 days prior to registration; CT/magnetic resonance imaging (MRI) of the chest/abdomen/pelvis within 45 days prior to registration; Patients must have IMDC intermediate (1-2 factors) or poor risk disease (>= 3 factors); Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial; Patients with measurable disease (node positive or metastatic) as defined by RECIST version 1.1 excluding the primary renal tumor; Patient not recommended for or refused immediate cytoreductive nephrectomy; Candidate for standard of care therapy with either immuno-oncology (IO)-IO or IO-VEGF combination regimen; Primary renal tumor measuring 20 cm or less in anterior to posterior dimension only on axial imaging; Age >= 18; Karnofsky performance status >= 60 within 45 days prior to registration; Hemoglobin >= 8 g/dL (transfusions are allowed) (within 45 days prior to registration); Platelet count >= 50,000/mm\^3 (within 45 days prior to registration); Absolute neutrophil count (ANC) >= 1500/mm\^3 (within 45 days prior to registration); Calculated (Calc.) creatinine clearance >= 30 mL/min (within 45 days prior to registration); Creatinine clearance (CrCl) >= 30 mL/min estimated by Cockcroft-Gault Equation; For African American patients specifically whose renal function is not considered adequate by the formula above, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) should be used for calculating the related estimated glomerular filtration rate (GFR) with a correction factor for African American race creatinine clearance for trial eligibility, where GFR >= 30 mL/min/1.73m\^2 will be considered adequate; Total bilirubin =< 1.5 x upper limit of normal (ULN) (except subjects with Gilbert Syndrome, who can have total bilirubin < 3.0 mg/dL) (within 45 days prior to registration); Aspartate aminotransferase and alanine aminotransferase (AST and ALT) =< 3 x upper limit of normal (ULN) or < 5 x ULN if hepatic metastases present (within 45 days prior to registration); Patients with known human immunodeficiency virus (HIV) on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial. Testing is not required for entry into protocol; For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated; Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. Patients with HCV infection who are currently on treatment are eligible if they have an undetectable HCV viral load; The patient must agree to use a highly effective contraception, including men with vasectomies if they are having sex with a woman of childbearing potential or with a woman who is pregnant, while on study drug and for 6 months following the last dose of study drug. Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal; The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information.
Exclusion: Patients with untreated or unstable brain metastases or cranial epidural disease; Note: Patients who have been adequately treated with radiotherapy, radiosurgery, or surgery and stable for at least 4 weeks prior to registration as documented by MRI or CT imaging or deemed stable by clinical investigator are eligible. Treated brain metastases are defined as having no ongoing requirement for steroids and no evidence of progression or hemorrhage after treatment for at least 4 weeks prior to registration as documented by MRI or CT imaging or deemed stable by clinical investigator; Prior radiotherapy to the kidney that would result in overlap of radiation therapy fields treatment of the primary tumor; Any systemic therapy for metastatic renal cell carcinoma (RCC) that was initiated > 90 days before registration, note that prior chemotherapy for a different cancer is allowed (completed > 3 years prior to registration); Severe, active comorbidity defined as follows:; Active autoimmune disease requiring ongoing therapy including systemic treatment with corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications daily. Inhaled steroids and adrenal replacement steroid doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease; History of severe allergic, anaphylactic or other hypersensitivity reactions to chimeric or humanized antibodies; Active tuberculosis (purified protein derivative [PPD] response without active tuberculosis [TB] is allowed); Uncontrolled hypertension (systolic blood pressure [BP] >= 190 mmHg or diastolic BP > 110 mmHg); Major surgery requiring hospital admission =< 28 days prior to registration; Any serious (requiring hospital stay or long term rehab) non-healing wound, ulcer, or bone fracture within 45 days prior to registration; Any arterial thrombotic (ST elevation myocardial infarction [STEMI], non-ST elevation myocardial infarction [NSTEMI], cerebrovascular accident [CVA], etc) events within 180 days prior to registration; Active New York (NY) Heart Association class 3-4 heart failure symptoms; Moderate or severe hepatic impairment (Child-Pugh B or C); Any history of untreated pulmonary embolism or deep venous thrombosis (DVT) within 180 days prior to registration. (Any asymptomatic or treated pulmonary embolism or asymptomatic treated deep venous thrombosis > 30 days prior to registration is allowed); Unstable cardiac arrhythmia within 180 days prior to registration; History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, bowel obstruction, or gastric outlet obstruction within 180 days prior to registration; History of or active inflammatory bowel disease; Malabsorption syndrome within 45 days prior to registration; Pregnancy and individuals unwilling to discontinue nursing. For women of child bearing potential must have a negative pregnancy test =< 45 days prior to registration; Patients with planned treatment of all metastatic disease with definitive therapy including either surgery, ablative (non-palliative) doses of radiation, or intervention of some type (definitive interventional radiology techniques) to ALL metastatic sites rendering the patient without extra-renal measurable disease. Patients NOT planned for definitive treatment of all metastatic sites are eligible. Lesions radiated palliatively are not eligible for response assessment.