Testing lower beta-blocker doses in people with atrial fibrillation
Tests a lower dose of beta-blocker in adults with atrial fibrillation, a heart rhythm disorder.
Plain-language title generated from the registry record
Registry title: The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation
Key facts
- Where
- Taipei, TaiwanSee the site
Where in Taiwan
- National Taiwan University HospitalTaipei, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Taiwan University Hospital
- Trial code
- NCT05332457
- Record updated
- 24 March 2025
- Original description
This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).Read full original descriptionShow less
The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation: a Crossover Randomized Controlled Trial.
This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).
Inclusion: > 20 years of age; Clinically stable patients with persistent atrial fibrillation using beta-blocker as rate-control agent without dosage adjustment for at least 3 months; Resting heart rate < 80 bpm; Left ventricular ejection fraction > 50%.
Exclusion: Beta-blocker usage due to indications other than rate control for atrial fibrillation; Inability to perform a cardiopulmonary exercise testing; Presence of contraindications for cardiopulmonary exercise testing according to the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription; Patients with implantable cardioverter defibrillator or pacemaker; Pregnancy; Inability to provide informed consent.