CPAP and Glucose Metabolism in Non-Diabetic OSA Subjects

Who can take part

• Community dwelling adult males and females aged 18-65 years
• Polysomnography confirmed moderate to severe OSA with apnea hypopnea index (AHI) ≥15/hr within the past 60 months
• Able to give written informed consent
• Proficient in English
• Diagnosed non-diabetic as defined by the American Diabetes Association as any of the following recent (<3 months) findings:
• Fasting glucose with a BGL <7.0 mmol/L
• Glucose tolerance with a 2-hour BGL of < 11.1 mmol/L after a formal 75g Oral Glucose Tolerance Test (OGTT)
• HbA1C of ≤ 6.5% 7. Possession or regular access to a mobile telephone with capability to download and run the Withings Sleep Anlayser App

Who cannot take part

• Regular (>2 times per month) use of sleep-affecting medication (e.g. benzodiazepines, opioids, antidepressants)
• Active smoking or routine alcohol use (more than 2 standard drinks a day) or excessive caffeine intake (>300 mg a day) or recent (in the past month) use of illicit drugs
• Current or previous diagnosis of diabetes mellitus (previous gestational diabetes mellitus not excluded)
• Clinically significant co-morbidity (e.g. myocardial infarction, congestive heart failure, stroke, arrythmia, chronic kidney or liver disease, epilepsy, head injury)
• Severe mental health disorders (e.g. current major depressive disorder, schizophrenia, bipolar disorder) that in the opinion of the investigator is not adequately treated or will significantly affect their participation in the study
• Contraindications for use of the FreeStyle Libre Pro Sensor. E.g. Known hypersensitivity to skin adhesives such as those used to attach the sensor to the arm
• Regular night shift work or travel overseas within the last 2 weeks
• Sleep physician has advised against CPAP withdrawal
• Pregnancy
• Current or recent (<3 months) use of hypoglycaemic agents
• Undergoing a weight loss programme