Frontlight ResearchEarly access
CompletedNo phase
The Effect of Acute Intermittent Hypoxia on Motor Learning
Key facts
- Who runs it
- University of Colorado, Boulder
- Where
- Aurora and Boulder, United StatesSee the 2 sites
- Trial code
- Status
- Completed
- People taking part
- 56 people enrolled
- Started
- 27 May 2022
- Ended
- 24 Feb 2025
- Type of study
- Interventional, 3 groupsOne group gets a sham (pretend) treatment, for comparison.
- Treatments tested
- Acute Intermittent Hypoxia
- SHAM Acute Intermittent Hypoxia
- Record updated
- 14 May 2025
Who can take part
- Age
- 18 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 17 criteriaShow less
Who can take part
- 18 to 70 years old (the latter to reduce likelihood of heart disease)
- Medically stable with medical clearance from physician to participate
- Motor-incomplete spinal cord injuries at or below C2 and at or above L5
- AIS A-D at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, ALS, tumors, acute transverse myelitis, etc.)
- More than 1 year since iSCI to minimize confounds of spontaneous neurological recovery
- Ability to advance one step overground with or without assistive devices
Who cannot take part
- Severe concurrent illness or pain
- Concurrent physical therapy
- Metal implants in the head, or pacemaker
- History of cardiovascular/pulmonary complications
- History of seizures or epilepsy
- Depression or manic disorders
- Recurrent autonomic dysreflexia
- Pregnant at time of enrollment or planning to become pregnant
- Untreated painful musculoskeletal dysfunction, fracture or pressure sore
- Recurring headaches
- Concussion within the last six months
Where in United States
- University of Colorado Anschutz Medical CampusAurora, United States
- University of ColoradoBoulder, United States
About the trial
What the trial wants to find out
The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.
The 3 groups in the trial
- Repetitive Acute Intermittent HypoxiaTreatment being tested
5 consecutive days of 15, 1.5 min episodes at 9% O2 (AIH) alternating with 21% O2 at 1 min intervals
Treatment: Acute Intermittent Hypoxia
- SHAM Acute Intermittent HypoxiaSham treatment, for comparison
5 consecutive days of 15, 1.5 min episodes at 21% O2 (SHAM AIH) alternating with 21% O2 at 1 min intervals
- ControlNo study treatment, for comparison
The control group received no AIH exposure.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Examining the Relationship Between Changes in Corticospinal Excitability and Motor Learning After Acute Intermittent Hypoxia in Able-bodied Individuals for Subsequent Study in Individuals With Incomplete Spinal Cord Injury.
- Publications
- Record updated
- 14 May 2025