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Taking people in IsraelPhase 4

Tranexamic acid tested to reduce bleeding during colon polyp removal

Tests tranexamic acid to limit bleeding during removal of large colon polyps.

Plain-language title generated from the registry record
Registry title: Tranexamic Acid During Colonic Endoscopic Resection Procedures

Key facts

Where
Be’er Ya‘aqov, IsraelSee the site
Phase
Phase 4

Where in Israel

  • Shamir Medical CenterBe’er Ya‘aqov, IsraelTaking people

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Trial details

Who runs it
Assaf-Harofeh Medical Center
Trial code
NCT05345613
Record updated
13 January 2026
Original description
Colonoscopy with polypectomy reduces the incidence and mortality associated with colon cancer. However, polypectomy is associated with adverse events such as bleeding. Tranexamic acid (TXA) is a synthetic derivative of lysine that exerts antifibrinolytic effects and may prevent bleeding. The investigators aim to evaluate the effect of local TXA on preventing intraprocedural and postprocedural bleeding in patients undergoing endoscopic mucosal resection (EMR) of large colon polyps.Read full original descriptionShow less

Usage of Tranexamic Acid During Colonic Endoscopic Resection Procedures for Reduction Intraprocedural and Postprocedural Bleeding

Colonoscopy with polypectomy reduces the incidence and mortality associated with colon cancer. However, polypectomy is associated with adverse events such as bleeding. Tranexamic acid (TXA) is a synthetic derivative of lysine that exerts antifibrinolytic effects and may prevent bleeding. The investigators aim to evaluate the effect of local TXA on preventing intraprocedural and postprocedural bleeding in patients undergoing endoscopic mucosal resection (EMR) of large colon polyps.

Inclusion: Patients referred for endoscopic resection of non-neoplastic and neoplastic lesions in the colon presenting to our tertiary academic center; Age > 18 years.

Exclusion: patients with histories of allergic reactions to TXA; history of seizures; pregnancy.

ClinicalTrials.gov NCT05345613