Testing a stool test for colorectal cancer screening and diagnosis
Compares a microRNA stool test with FIT in adults screened for colorectal cancer.
Plain-language title generated from the registry record
Registry title: Validation of a microRNA-based Fecal (miRFec) Test for Colorectal Cancer Screening, Surveillance and Diagnosis
Key facts
- Where
- Barcelona, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who are referred to colonoscopy for colorectal cancer screening, follow-up after polyps or cancer, or because of bowel symptoms. It tests a stool test called miRFec.
- Age
- 18 to 80 years. People in average-risk screening are 50 to 75. People with a family history of colorectal cancer are 30 to 80. The other groups are 18 or older.
- Sex
- Men and women can join.
- Disease stage
- The trial is looking for people referred to colonoscopy for screening, follow-up (surveillance) after colorectal polyps or colorectal cancer, or diagnosis of bowel symptoms.
Main reasons for not taking part
- Did not give informed consent
- Lynch syndrome in the person
- Polyposis (adenomatous, hamartomatous or serrated) in the person
- Inflammatory bowel disease
- Total colectomy (removal of the whole colon) for any reason
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT05346757, who can take part
Where in Spain
- Hospital Clinic of BarcelonaBarcelona, SpainContact: Mireia DiazTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Fundacion Clinic per a la Recerca Biomédica
- Trial code
- NCT05346757
- Record updated
- 13 March 2025
- Original description
The present study aims to compare effectiveness and cost-effectiveness of the miRFec test with respect to fecal immunochemical test (FIT) for the detection of advanced colorectal neoplasm among individuals participating in colorectal cancer (CRC) screening, surveillance and diagnosis.Read full original descriptionShow less
Prospective, Multicenter, Comparative, Paired Study to Validate a microRNA-based Fecal Test for Colorectal Cancer Screening. The miRFec Study
The present study aims to compare effectiveness and cost-effectiveness of the miRFec test with respect to fecal immunochemical test (FIT) for the detection of advanced colorectal neoplasm among individuals participating in colorectal cancer (CRC) screening, surveillance and diagnosis.
Inclusion: Male or female aged 50 to 75 (average-risk) referred to colonoscopy-based CRC screening; Male or female aged 30 to 80 with family history of CRC (moderate-risk) referred to colonoscopy-based CRC screening; Male and female aged 18 or older with personal history of colorectal polyps referred to colonoscopy surveillance; Male and female aged 18 or older with personal history of CRC referred to colonoscopy surveillance; Male and female aged 18 or older with colorectal symptoms referred to diagnostic colonoscopy.
Exclusion: Personal history of Lynch syndrome; Personal history of adenomatous or hamartomatous polyposis; Personal history of serrated polyposis syndrome; Personal history of inflammatory bowel disease; Personal history of total colectomy for any reason; Family history of Lynch syndrome; Family history of adenomatous or hamartomatous polyposis; Family history of serrated polyposis syndrome; Lack of informed consent to participate.