Tests sauna-style heat therapy against lung bacteria in adults with chronic lung disease
Tests frequent heat therapy to reduce persistent bacteria in adults with chronic lung disease.
Plain-language title generated from the registry record
Registry title: THERMotherapy Against Persistent Bacterial LUNG Infections
Key facts
- Where
- Hellerup, DenmarkSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with lasting bacterial lung infections who have had repeated positive cultures. It tests whether regular sauna baths can reduce or clear the bacteria.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Lung infection with certain bacteria (for example Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus influenzae). Lung function FEV1 above 1,0 L.
- Earlier treatment
- At least 1 positive culture after treatment with antibiotics.
- Biomarker or test result
- At least 2 positive sputum or BAL cultures in the last 24 months for one of the named bacteria.
Main reasons for not taking part
- Allergy to lidocaine or midazolam
- Reasons that make a bronchoscopy unsafe
- Previous severe laryngospasm that needed intubation
- Pregnancy or breastfeeding
- Severe mental illness not controlled with medication
Read by machine on 12 November 2026.
Where in Denmark
- Herlev and Gentofte University HospitalHellerup, DenmarkContact: josefin V Eklöf, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
- Trial code
- NCT05351242
- Record updated
- 6 November 2026
- Original description
The aim of this study is to determine whether an intervention with frequent thermotherapy will be able to reduce the amount of colonizing bacteria in the bronchoalveolar lavage sample and eradicate the colonizing bacteria.Read full original descriptionShow less
Thermotherapy Against Persistent Bacterial LUNG Infections
The aim of this study is to determine whether an intervention with frequent thermotherapy will be able to reduce the amount of colonizing bacteria in the bronchoalveolar lavage sample and eradicate the colonizing bacteria.
Inclusion: Age ≥ 18 years; Competent and capable; FEV1>1,0 L; Have had a positive culture from sputum or BAL min. 2 times in the last 24 months for bacteria of the species: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Staphylococcus aureus, Haemophilus influenzae, Achromobacter xylosoxidans, Klebsiella oxytoca or Klebsiella pneumoniae. In addition, min. 1 positive culture after treatment with antibiotics; Willing to go to a sauna (min. temperature of 85℃ for at least 7 minutes) four times weekly for six months or avoid going to a sauna for six months.
Exclusion: Previous severe laryngospasm (intubation requiring); Allergy to lidocaine and/or midazolam; Severe mental illness that is not controlled with medication. NB: Patients with controlled mental illness can be included and will be asked on an equal footing as others; Contraindications to bronchoscopy; Pregnancy/breastfeeding; Severe linguistic problems or inability to give informed consent.