Home-Based Cognitive and Motor Training for People With Multiple Sclerosis
Tests home-based computer training for thinking and movement in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Cognitive-motor Telerehabilitation in MS
Key facts
- Where
- Brussels and Melsbroek, BelgiumSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT05355389, who can take part
Where in Belgium
- Universitair Ziekenhuis BrusselBrussels, BelgiumTaking people
- National MS Center MelsbroekMelsbroek, BelgiumTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universitair Ziekenhuis Brussel
- Trial code
- NCT05355389
- Record updated
- 8 May 2026
- Original description
The primary goal of this project is providing evidence that a home-based combined cognitive-motor training program improves cognition in persons with multiple sclerosis (MS), compared to single cognitive and motor rehabilitation. Secondary goals are to assess the effects on walking performance and to identify the mechanisms of improvement and predictors of treatment response. The main backbone of this project will be a randomized controlled two-centre clinical trial, in which an at-home computerised cognitive-motor rehabilitation program using telemedicine aimed at improving working memory in persons with MS will be evaluated. Based on the information gathered during this trial, possible mechanisms of improvement will be identified by analysing anatomical and neurophysiological changes on structural MRI and resting-state and task-related EEG before and after rehabilitation. Furthermore, factors that can predict treatment response to the rehabilitation program will be identified.Read full original descriptionShow less
Cognitive-motor Telerehabilitation in Multiple Sclerosis
The primary goal of this project is providing evidence that a home-based combined cognitive-motor training program improves cognition in persons with multiple sclerosis (MS), compared to single cognitive and motor rehabilitation. Secondary goals are to assess the effects on walking performance and to identify the mechanisms of improvement and predictors of treatment response. The main backbone of this project will be a randomized controlled two-centre clinical trial, in which an at-home computerised cognitive-motor rehabilitation program using telemedicine aimed at improving working memory in persons with MS will be evaluated. Based on the information gathered during this trial, possible mechanisms of improvement will be identified by analysing anatomical and neurophysiological changes on structural MRI and resting-state and task-related EEG before and after rehabilitation. Furthermore, factors that can predict treatment response to the rehabilitation program will be identified.
Inclusion: Clinically definite multiple sclerosis (revised McDonald criteria 2017); Expanded Disability Status Scale (EDSS) below 6.0; Digit span backwards z-score between [-3 and -0.5] standard deviations below the median of the normative values; Age between 18 and 65; Able to safely perform motor rehabilitation in the home situation (assessed by rehabilitation physician and/or occupational or physiotherapist).
Exclusion: Cognitive rehabilitation within six months before inclusion; Inpatient multidisciplinary rehabilitation program within three months before inclusion or planned inpatient program during trial; Start of or switch in immunomodulator treatment within three months before inclusion; Major psychiatric or medical disorder that could influence cognitive functions; Less than one month post-exacerbation; Combined vision with optimal correction below 0.6 on Snellen Visual Acuity Test; Unable or unwilling to undergo EEG or MRI; Refusing informed consent.