NCT05355415Recruiting
Adaptive Optics Imaging of Outer Retinal Diseases
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 19 Apr 2022
- Start date
- 27 Aug 2021
- Primary completion date
- 30 Sept 2028
- Lead sponsor
- Food and Drug Administration (FDA)
- Diseases
- Macular degeneration, Retinitis pigmentosa
- NCT number
- NCT05355415
What you commit to
- Study type: Observational
- Planned participants: 100
- From 27 Aug 2021 to the primary completion date, 30 Sept 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity),
- Have a history of adverse reaction to mydriatic drops,
- Have a predisposition to (i.e., narrow iridocorneal angle) or any history of acute angle closure glaucoma (AACG), or
Other
- Have visual correction outside of the range +4 diopters (D) to -8 D,
- Are working under the direct supervision of Drs. Hammer, Cukras and Liu, or any of the NIH/NEI AIs.
Who the study is looking for
- Are 21 years of age or older,
- Have the ability to cooperate with instructions during adaptive optics imaging (similar to instructions given during a clinical eye exam),
- Have the ability to understand and sign an informed consent. (Non-English speaking participants will not be enrolled into the study), and
- Have been diagnosed with outer retinal disease or condition (Cohort 2).
Age in the registry: 21 years to - · Sex: All
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NIH Clinical Center Coordinator of this site? Confirm its status | Bethesda | United States | Recruiting |
| Food and Drug Administration Coordinator of this site? Confirm its status | Silver Spring | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.