Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer
Reason given: lack of accrual
Key facts
- Where
- Albuquerque, Altoona, Anaconda, Anaheim, Ann Arbor, Asheville, Ashland, Auburn, Baldwin Park, Barrington, Battle Creek, Beaver, Bellflower, Bemidji, Berkeley, Billings, Bismarck, Bloomington, Boiling Springs, Boise, Bozeman, Brainerd, Brighton, Burlington, Butler, Caldwell, Camp Hill, Canton, Cape Girardeau, Carlisle, Carthage, Centerville, Centralia, Chambersburg, Charleston, Chelsea, Chicago, Cleveland, Clyde, Coeur d'Alene, Collierville, Columbus, Concord, Coon Rapids, Cranberry Township, Crystal Lake, Cumberland, Danville, Dayton, Decatur, Deer River, DeKalb, Des Moines, Detroit, Dixon, Downers Grove, Duluth, Easley, East China Township, Edina, Effingham, Elgin, Ephrata, Erie, Eureka, Fargo, Farmington, Farrell, Flint, Fontana, Franklin, Fremont, Fruitland, Galesburg, Geneva, Germantown, Gettysburg, Grafton, Grand Rapids, Great Falls, Green Bay, Greensburg, Greenville, Greer, Grenada, Grosse Pointe Woods, Harbor City, Harrisburg, Hays, Hazel Crest, Hendersonville, Hibbing, Indiana, Irvine, Johnstown, Jonesboro, Kalamazoo, Kalispell, Kansas City, Kenosha, Kewanee, La Crosse, Lake Forest, Lansing, Las Vegas, Lawrence, Lebanon, Lee's Summit, Lexington, Libertyville, Little Rock, Livonia, Loma Linda, Los Angeles, Macomb, Manchester, Mansfield, Marinette, Mattoon, Mayfield Heights, McKeesport, Mechanicsburg, Memphis, Meridian, Miami Beach, Milwaukee, Minneapolis, Missoula, Monroeville, Moon Township, Moorestown, Muskegon, N. Huntingdon, Nampa, Natrona Heights, New Albany, New Castle, North Kansas City, Norton Shores, O'Fallon, Oak Lawn, Olathe, Ontario, Oshkosh, Ottawa, Overland Park, Oxford, Palo Alto, Panorama City, Park Ridge, Pekin, Peoria, Peru, Pittsburgh, Portland, Post Falls, Princeton, Racine, Reed City, Riverside, Rochester, Roseville, Sacramento, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Salina, San Diego, San Francisco, San Marcos, Sandpoint, Sandstone, Sandusky, Seneca, Sheboygan, Sioux Falls, Southhaven, Springfield, St Louis, St. Helena, Sterling Heights, Steubenville, Strongsville, Sullivan, Summit, Sunnyvale, Sunset Hills, Sylvania, Tampa, Topeka, Traverse City, Troy, Twin Falls, Two Rivers, Uniontown, Urbana, Vallejo, Virginia, Voorhees Township, Warren, Warrensville Heights, Warrenville, Washington, Wauwatosa, Weaverville, West Allis, West Mifflin, Westwood, Whittier, Woodland Hills, Wooster, Wyoming, York, and Ypsilanti, United StatesSee the 265 sites
- Phase
- Phase 2
Where in United States
- University of New Mexico Cancer CenterAlbuquerque, United StatesNo longer taking part
- UPMC AltoonaAltoona, United StatesNo longer taking part
- Community Hospital of AnacondaAnaconda, United StatesNo longer taking part
- Kaiser Permanente-AnaheimAnaheim, United StatesNo longer taking part
- Saint Joseph Mercy HospitalAnn Arbor, United StatesNo longer taking part
- AdventHealth Infusion Center AshevilleAsheville, United StatesNo longer taking part
- Duluth Clinic AshlandAshland, United StatesNo longer taking part
- Sutter Auburn Faith HospitalAuburn, United StatesNo longer taking part
- Kaiser Permanente-Baldwin ParkBaldwin Park, United StatesNo longer taking part
- Advocate Good Shepherd HospitalBarrington, United StatesNo longer taking part
- Bronson Battle CreekBattle Creek, United StatesNo longer taking part
- UPMC-Heritage Valley Health System BeaverBeaver, United StatesNo longer taking part
- Kaiser Permanente-BellflowerBellflower, United StatesNo longer taking part
- Sanford Joe Lueken Cancer CenterBemidji, United StatesNo longer taking part
- Alta Bates Summit Medical Center-Herrick CampusBerkeley, United StatesNo longer taking part
- Billings Clinic Cancer CenterBillings, United StatesNo longer taking part
- Sanford Bismarck Medical CenterBismarck, United StatesNo longer taking part
- Illinois CancerCare-BloomingtonBloomington, United StatesNo longer taking part
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesNo longer taking part
- Saint Luke's Cancer Institute - BoiseBoise, United StatesNo longer taking part
- Bozeman Deaconess HospitalBozeman, United StatesNo longer taking part
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesNo longer taking part
- Saint Joseph Mercy BrightonBrighton, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesNo longer taking part
- Aurora Cancer Care-Southern Lakes VLCCBurlington, United StatesNo longer taking part
- UPMC Hillman Cancer Center at Butler Health SystemButler, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesNo longer taking part
- UPMC Camp HillCamp Hill, United StatesNo longer taking part
- Aultman Health FoundationCanton, United StatesNo longer taking part
- Illinois CancerCare-CantonCanton, United StatesNo longer taking part
- Saint Joseph Mercy CantonCanton, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesNo longer taking part
- Saint Francis Medical CenterCape Girardeau, United StatesNo longer taking part
- Carlisle Regional Cancer CenterCarlisle, United StatesNo longer taking part
- Illinois CancerCare-CarthageCarthage, United StatesNo longer taking part
- Miami Valley Hospital SouthCenterville, United StatesNo longer taking part
- Centralia Oncology ClinicCentralia, United StatesNo longer taking part
- WellSpan Medical Oncology and HematologyChambersburg, United StatesNo longer taking part
- Medical University of South CarolinaCharleston, United StatesNo longer taking part
- Ralph H. Johnson VA Medical CenterCharleston, United StatesNo longer taking part
- Saint Joseph Mercy ChelseaChelsea, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesNo longer taking part
- Advocate Illinois Masonic Medical CenterChicago, United StatesNo longer taking part
- Northwestern UniversityChicago, United StatesNo longer taking part
- Cleveland Clinic Cancer Center/Fairview HospitalCleveland, United StatesNo longer taking part
- Cleveland Clinic FoundationCleveland, United StatesNo longer taking part
- AdventHealth Infusion Center HaywoodClyde, United StatesNo longer taking part
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, United StatesNo longer taking part
- New Hampshire Oncology Hematology PA-ConcordConcord, United StatesNo longer taking part
- Mercy HospitalCoon Rapids, United StatesNo longer taking part
- UPMC Hillman Cancer Center - Passavant - CranberryCranberry Township, United StatesNo longer taking part
- AMG Crystal Lake - OncologyCrystal Lake, United StatesNo longer taking part
- UPMC Western MarylandCumberland, United StatesNo longer taking part
- Carle on VermilionDanville, United StatesNo longer taking part
- Miami Valley HospitalDayton, United StatesNo longer taking part
- Miami Valley Hospital NorthDayton, United StatesNo longer taking part
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesNo longer taking part
- Decatur Memorial HospitalDecatur, United StatesNo longer taking part
- Essentia Health - Deer River ClinicDeer River, United StatesNo longer taking part
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesNo longer taking part
- Mercy Medical Center - Des MoinesDes Moines, United StatesNo longer taking part
- Ascension Saint John HospitalDetroit, United StatesNo longer taking part
- Illinois CancerCare-DixonDixon, United StatesNo longer taking part
- Advocate Good Samaritan HospitalDowners Grove, United StatesNo longer taking part
- Essentia Health Cancer CenterDuluth, United StatesNo longer taking part
- Prisma Health Cancer Institute - EasleyEasley, United StatesNo longer taking part
- Great Lakes Cancer Management Specialists-Doctors ParkEast China Township, United StatesNo longer taking part
- Fairview Southdale HospitalEdina, United StatesNo longer taking part
- Carle Physician Group-EffinghamEffingham, United StatesNo longer taking part
- Crossroads Cancer CenterEffingham, United StatesNo longer taking part
- Advocate Sherman HospitalElgin, United StatesNo longer taking part
- Ephrata Cancer CenterEphrata, United StatesNo longer taking part
- UPMC Hillman Cancer Center ErieErie, United StatesNo longer taking part
- Illinois CancerCare-EurekaEureka, United StatesNo longer taking part
- Essentia Health Cancer Center-South University ClinicFargo, United StatesNo longer taking part
- Sanford Broadway Medical CenterFargo, United StatesNo longer taking part
- Sanford Roger Maris Cancer CenterFargo, United StatesNo longer taking part
- Parkland Health Center - FarmingtonFarmington, United StatesNo longer taking part
- UPMC Cancer Center at UPMC HorizonFarrell, United StatesNo longer taking part
- Genesee Cancer and Blood Disease Treatment CenterFlint, United StatesNo longer taking part
- Genesee Hematology Oncology PCFlint, United StatesNo longer taking part
- Genesys Hurley Cancer InstituteFlint, United StatesNo longer taking part
- Hurley Medical CenterFlint, United StatesNo longer taking part
- Kaiser Permanente-FontanaFontana, United StatesNo longer taking part
- Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesNo longer taking part
- Palo Alto Medical Foundation-FremontFremont, United StatesNo longer taking part
- Saint Luke's Cancer Institute - FruitlandFruitland, United StatesNo longer taking part
- Illinois CancerCare-GalesburgGalesburg, United StatesNo longer taking part
- Northwestern Medicine Cancer Center DelnorGeneva, United StatesNo longer taking part
- Aurora Health Care Germantown Health CenterGermantown, United StatesNo longer taking part
- Adams Cancer CenterGettysburg, United StatesNo longer taking part
- Aurora Cancer Care-GraftonGrafton, United StatesNo longer taking part
- Spectrum Health at Butterworth CampusGrand Rapids, United StatesNo longer taking part
- Benefis Healthcare- Sletten Cancer InstituteGreat Falls, United StatesNo longer taking part
- Aurora BayCare Medical CenterGreen Bay, United StatesNo longer taking part
- UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, United StatesNo longer taking part
- Oncology Hematology AssociatesGreenville, United StatesNo longer taking part
- Prisma Health Cancer Institute - ButternutGreenville, United StatesNo longer taking part
- Prisma Health Cancer Institute - EastsideGreenville, United StatesNo longer taking part
- Prisma Health Cancer Institute - FarisGreenville, United StatesNo longer taking part
- Prisma Health Greenville Memorial HospitalGreenville, United StatesNo longer taking part
- Prisma Health Cancer Institute - GreerGreer, United StatesNo longer taking part
- Baptist Cancer Center-GrenadaGrenada, United StatesNo longer taking part
- Academic Hematology Oncology SpecialistsGrosse Pointe Woods, United StatesNo longer taking part
- Great Lakes Cancer Management Specialists-Van Elslander Cancer CenterGrosse Pointe Woods, United StatesNo longer taking part
- Kaiser Permanente - Harbor CityHarbor City, United StatesNo longer taking part
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, United StatesNo longer taking part
- HaysMed University of Kansas Health SystemHays, United StatesNo longer taking part
- Advocate South Suburban HospitalHazel Crest, United StatesNo longer taking part
- AdventHealth HendersonvilleHendersonville, United StatesNo longer taking part
- Essentia Health Hibbing ClinicHibbing, United StatesNo longer taking part
- IRMC Cancer CenterIndiana, United StatesNo longer taking part
- Kaiser Permanente-IrvineIrvine, United StatesNo longer taking part
- UPMC-Johnstown/John P. Murtha Regional Cancer CenterJohnstown, United StatesNo longer taking part
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, United StatesNo longer taking part
- Bronson Methodist HospitalKalamazoo, United StatesNo longer taking part
- West Michigan Cancer CenterKalamazoo, United StatesNo longer taking part
- Kalispell Regional Medical CenterKalispell, United StatesNo longer taking part
- Truman Medical CentersKansas City, United StatesNo longer taking part
- University of Kansas Cancer CenterKansas City, United StatesNo longer taking part
- University of Kansas Cancer Center - NorthKansas City, United StatesNo longer taking part
- Aurora Cancer Care-Kenosha SouthKenosha, United StatesNo longer taking part
- Illinois CancerCare-Kewanee ClinicKewanee, United StatesNo longer taking part
- Gundersen Lutheran Medical CenterLa Crosse, United StatesNo longer taking part
- Northwestern Medicine Lake Forest HospitalLake Forest, United StatesNo longer taking part
- Sparrow HospitalLansing, United StatesNo longer taking part
- OptumCare Cancer Care at CharlestonLas Vegas, United StatesNo longer taking part
- OptumCare Cancer Care at Fort ApacheLas Vegas, United StatesNo longer taking part
- Lawrence Memorial HospitalLawrence, United StatesNo longer taking part
- Sechler Family Cancer CenterLebanon, United StatesNo longer taking part
- University of Kansas Cancer Center - Lee's SummitLee's Summit, United StatesNo longer taking part
- University of Kentucky/Markey Cancer CenterLexington, United StatesNo longer taking part
- AMG Libertyville - OncologyLibertyville, United StatesNo longer taking part
- Condell Memorial HospitalLibertyville, United StatesNo longer taking part
- University of Arkansas for Medical SciencesLittle Rock, United StatesNo longer taking part
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesNo longer taking part
- Loma Linda University Medical CenterLoma Linda, United StatesNo longer taking part
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesNo longer taking part
- Kaiser Permanente West Los AngelesLos Angeles, United StatesNo longer taking part
- Great Lakes Cancer Management Specialists-Macomb Medical CampusMacomb, United StatesNo longer taking part
- Illinois CancerCare-MacombMacomb, United StatesNo longer taking part
- Solinsky Center for Cancer CareManchester, United StatesNo longer taking part
- Cleveland Clinic Cancer Center MansfieldMansfield, United StatesNo longer taking part
- Aurora Bay Area Medical Group-MarinetteMarinette, United StatesNo longer taking part
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesNo longer taking part
- Hillcrest Hospital Cancer CenterMayfield Heights, United StatesNo longer taking part
- UPMC Cancer Center at UPMC McKeesportMcKeesport, United StatesNo longer taking part
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-MemphisMemphis, United StatesNo longer taking part
- Saint Luke's Cancer Institute - MeridianMeridian, United StatesNo longer taking part
- Mount Sinai Medical CenterMiami Beach, United StatesNo longer taking part
- Aurora Cancer Care-MilwaukeeMilwaukee, United StatesNo longer taking part
- Aurora Saint Luke's Medical CenterMilwaukee, United StatesNo longer taking part
- Aurora Sinai Medical CenterMilwaukee, United StatesNo longer taking part
- Minneapolis VA Medical CenterMinneapolis, United StatesNo longer taking part
- Community Medical HospitalMissoula, United StatesNo longer taking part
- UPMC Cancer Center - MonroevilleMonroeville, United StatesNo longer taking part
- UPMC Hillman Cancer Center - MonroevilleMonroeville, United StatesNo longer taking part
- UPMC Hillman Cancer Center in CoraopolisMoon Township, United StatesNo longer taking part
- Virtua Samson Cancer CenterMoorestown, United StatesNo longer taking part
- Trinity Health Muskegon HospitalMuskegon, United StatesNo longer taking part
- Arnold Palmer Cancer Center Medical Oncology NorwinN. Huntingdon, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-NampaNampa, United StatesNo longer taking part
- Saint Luke's Cancer Institute - NampaNampa, United StatesNo longer taking part
- UPMC Cancer Center-Natrona HeightsNatrona Heights, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, United StatesNo longer taking part
- UPMC Hillman Cancer Center - New CastleNew Castle, United StatesNo longer taking part
- University of Kansas Cancer Center at North Kansas City HospitalNorth Kansas City, United StatesNo longer taking part
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesNo longer taking part
- Cancer Care Center of O'FallonO'Fallon, United StatesNo longer taking part
- Advocate Christ Medical CenterOak Lawn, United StatesNo longer taking part
- Olathe Health Cancer CenterOlathe, United StatesNo longer taking part
- Kaiser Permanente-OntarioOntario, United StatesNo longer taking part
- Saint Alphonsus Medical Center-OntarioOntario, United StatesNo longer taking part
- Vince Lombardi Cancer Clinic - OshkoshOshkosh, United StatesNo longer taking part
- Illinois CancerCare-Ottawa ClinicOttawa, United StatesNo longer taking part
- University of Kansas Cancer Center-Overland ParkOverland Park, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-OxfordOxford, United StatesNo longer taking part
- Palo Alto Medical Foundation Health CarePalo Alto, United StatesNo longer taking part
- Kaiser Permanente - Panorama CityPanorama City, United StatesNo longer taking part
- Advocate Lutheran General HospitalPark Ridge, United StatesNo longer taking part
- Illinois CancerCare-PekinPekin, United StatesNo longer taking part
- Illinois CancerCare-PeoriaPeoria, United StatesNo longer taking part
- Illinois CancerCare-PeruPeru, United StatesNo longer taking part
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, United StatesNo longer taking part
- UPMC-Mercy HospitalPittsburgh, United StatesNo longer taking part
- UPMC-Passavant HospitalPittsburgh, United StatesNo longer taking part
- UPMC-Saint Clair Hospital Cancer CenterPittsburgh, United StatesNo longer taking part
- UPMC-Saint MargaretPittsburgh, United StatesNo longer taking part
- Kaiser Permanente NorthwestPortland, United StatesNo longer taking part
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesNo longer taking part
- Illinois CancerCare-PrincetonPrinceton, United StatesNo longer taking part
- Aurora Cancer Care-RacineRacine, United StatesNo longer taking part
- Spectrum Health Reed City HospitalReed City, United StatesNo longer taking part
- Kaiser Permanente-RiversideRiverside, United StatesNo longer taking part
- University of RochesterRochester, United StatesNo longer taking part
- Sutter Roseville Medical CenterRoseville, United StatesNo longer taking part
- Sutter Medical Center SacramentoSacramento, United StatesNo longer taking part
- University of California Davis Comprehensive Cancer CenterSacramento, United StatesNo longer taking part
- Marie Yeager Cancer CenterSaint Joseph, United StatesNo longer taking part
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesNo longer taking part
- Regions HospitalSaint Paul, United StatesNo longer taking part
- United HospitalSaint Paul, United StatesNo longer taking part
- Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesNo longer taking part
- Salina Regional Health CenterSalina, United StatesNo longer taking part
- Kaiser Permanente-San Diego ZionSan Diego, United StatesNo longer taking part
- California Pacific Medical Center-Pacific CampusSan Francisco, United StatesNo longer taking part
- Veterans Affairs Medical Center - San FranciscoSan Francisco, United StatesNo longer taking part
- Kaiser Permanente-San MarcosSan Marcos, United StatesNo longer taking part
- Kootenai Cancer ClinicSandpoint, United StatesNo longer taking part
- Essentia Health SandstoneSandstone, United StatesNo longer taking part
- North Coast Cancer CareSandusky, United StatesNo longer taking part
- Prisma Health Cancer Institute - SenecaSeneca, United StatesNo longer taking part
- UPMC Cancer Center at UPMC NorthwestSeneca, United StatesNo longer taking part
- Vince Lombardi Cancer Clinic-SheboyganSheboygan, United StatesNo longer taking part
- Sanford Cancer Center Oncology ClinicSioux Falls, United StatesNo longer taking part
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, United StatesNo longer taking part
- Memorial Medical CenterSpringfield, United StatesNo longer taking part
- Southern Illinois University School of MedicineSpringfield, United StatesNo longer taking part
- Springfield ClinicSpringfield, United StatesNo longer taking part
- Missouri Baptist Medical CenterSt Louis, United StatesNo longer taking part
- Saint Helena HospitalSt. Helena, United StatesNo longer taking part
- Bhadresh Nayak MD PC-Sterling HeightsSterling Heights, United StatesNo longer taking part
- Trinity's Tony Teramana Cancer CenterSteubenville, United StatesNo longer taking part
- Cleveland Clinic Cancer Center StrongsvilleStrongsville, United StatesNo longer taking part
- Missouri Baptist Sullivan HospitalSullivan, United StatesNo longer taking part
- Aurora Medical Center in SummitSummit, United StatesNo longer taking part
- Palo Alto Medical Foundation-SunnyvaleSunnyvale, United StatesNo longer taking part
- Missouri Baptist Outpatient Center-Sunset HillsSunset Hills, United StatesNo longer taking part
- ProMedica Flower HospitalSylvania, United StatesNo longer taking part
- Moffitt Cancer CenterTampa, United StatesNo longer taking part
- University of Kansas Health System Saint Francis CampusTopeka, United StatesNo longer taking part
- Munson Medical CenterTraverse City, United StatesNo longer taking part
- Upper Valley Medical CenterTroy, United StatesNo longer taking part
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, United StatesNo longer taking part
- Vince Lombardi Cancer Clinic-Two RiversTwo Rivers, United StatesNo longer taking part
- UPMC Cancer Center-UniontownUniontown, United StatesNo longer taking part
- UPMC Uniontown Hospital Radiation OncologyUniontown, United StatesNo longer taking part
- Carle Cancer CenterUrbana, United StatesNo longer taking part
- Sutter Solano Medical Center/Cancer CenterVallejo, United StatesNo longer taking part
- Essentia Health Virginia ClinicVirginia, United StatesNo longer taking part
- Virtua VoorheesVoorhees Township, United StatesNo longer taking part
- Great Lakes Cancer Management Specialists-Macomb Professional BuildingWarren, United StatesNo longer taking part
- Saint John Macomb-Oakland HospitalWarren, United StatesNo longer taking part
- South Pointe HospitalWarrensville Heights, United StatesNo longer taking part
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesNo longer taking part
- UPMC Washington Hospital Radiation OncologyWashington, United StatesNo longer taking part
- Aurora Cancer Care-Milwaukee WestWauwatosa, United StatesNo longer taking part
- AdventHealth Infusion Center WeavervilleWeaverville, United StatesNo longer taking part
- Aurora West Allis Medical CenterWest Allis, United StatesNo longer taking part
- UPMC West Mifflin-Cancer Center JeffersonWest Mifflin, United StatesNo longer taking part
- University of Kansas Hospital-Westwood Cancer CenterWestwood, United StatesNo longer taking part
- Presbyterian Intercommunity HospitalWhittier, United StatesNo longer taking part
- Kaiser Permanente-Woodland HillsWoodland Hills, United StatesNo longer taking part
- Cleveland Clinic Wooster Family Health and Surgery CenterWooster, United StatesNo longer taking part
- Metro Health HospitalWyoming, United StatesNo longer taking part
- UPMC MemorialYork, United StatesNo longer taking part
- WellSpan Health-York Cancer CenterYork, United StatesNo longer taking part
- WellSpan Health-York HospitalYork, United StatesNo longer taking part
- Huron Gastroenterology PCYpsilanti, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesNo longer taking part
Trial details
- Who runs it
- SWOG Cancer Research Network
- Trial code
- NCT05364645
- Record updated
- 9 July 2024
- Original description
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving selpercatinib in combination with carboplatin and pemetrexed may help lower the chance of the cancer growing and spreading.Read full original descriptionShow less
A Randomized Phase II Study of Carboplatin and Pemetrexed w/ or w/o Selpercatinib in Participants With Non-Squamous RET Fusion-Positive Stage IV Non-Small Cell Lung Cancer and Progression of Disease on Prior RET Directed Therapy (Lung-MAP Sub-Study)
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving selpercatinib in combination with carboplatin and pemetrexed may help lower the chance of the cancer growing and spreading.
Inclusion: Participants must have stage IV or recurrent disease; Participants must have been assigned to S1900F based on biomarker analysis of tissue and/or blood and determined to have RET fusion-positive NSCLC as defined here:; Participants must have RET fusion-positive NSCLC as determined by the Foundation Medicine (FMI) tissue-assay or other tumor-based assays such as next generation sequencing (NGS), polymerase chain reaction (PCR), or fluorescent in situ hybridization (FISH), or by cfDNA blood assay as outlined in the LUNGMAP Screening Protocol. Participants previously tested for and determined to have RET-fusion-positive NSCLC outside of LUNGMAP, must also submit tissue for central FMI testing on the LUNGMAP Screening Protocol. Participants with RET fusions detected by IHC alone are not eligible. The testing must be done within a laboratory with Clinical Laboratory Improvement Act (CLIA), International Organization for Standardization (ISO)/International Electrotechnical Commission (IEC), College of American Pathologists (CAP), or similar certification. Presence of RET fusions detected on tests performed outside of LUNGMAP must have been confirmed by the study biomarker review panel; Participants must be negative for all additional validated oncogenic drivers that could cause resistance to selpercatinib treatment. This includes EGFR sensitizing mutations, EGFR T790M mutations, ALK gene fusions, ROS1 gene fusion, KRAS activating mutations, BRAF V600E mutation and MET exon 14 skipping mutations or high-level amplification and expression; NOTE: EGFR, ALK, ROS, KRAS, and BRAF testing is performed as part of the LUNGMAP screening/pre-screening FoundationOne test. If prior data is not available, results from the FMI testing must be obtained prior to sub-study randomization; Participants must have measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI). The CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality. Measurable disease must be assessed within 28 days prior to sub-study randomization. Pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. Non-measurable disease must be assessed within 42 days prior to sub-study randomization. All disease must be assessed and documented on the Baseline Tumor Assessment Form. Participants whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to randomization; Participants must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to sub-study randomization; Participants must have received and developed disease progression during or after an anti-RET inhibitors treatment. The anti-RET inhibitor therapy must be the most recent therapy; Participants must have progressed (in the opinion of the treating physician) following the most recent line of therapy; Participants must have recovered (=< grade 1) from any side effects of prior therapy. Participants must not have received any radiation therapy within 14 days prior to sub-study randomization; For participants with stage IV or recurrent disease, the participant must not have received a platinum-based chemotherapy regimen. For participants whose prior systemic therapy was for stage I-III disease only (i.e., participant has not received any treatment for stage IV or recurrent disease), disease progression on platinum-based chemotherapy must not have occurred within one year (365 days) from the last date that the participant received that therapy. Prior anti-PD-1/PD-L1 therapy, alone or in combination (e.g., nivolumab, pembrolizumab, or durvalumab) is allowed; Participants must have an electrocardiogram (ECG) performed within 28 days prior to sub-study randomization. It is suggested that a local cardiologist review the corrected QT by Fridericia's correction formula (QTcF) intervals; Absolute neutrophil count (ANC) >= 1.5 x 10\^3/uL obtained within 28 days prior to sub-study randomization; Platelet count >= 100 x 10\^3/uL obtained within 28 days prior to sub-study randomization; Hemoglobin >= 9 g/dL obtained within 28 days prior to sub-study randomization; Serum bilirubin =< institutional upper limit of normal (IULN) and either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN within 28 days prior to sub-study randomization (if both ALT and AST are done, both must be < 2 x IULN). For participants with liver metastases, bilirubin and either ALT or AST must be =< 5 x IULN (if both ALT and AST are done, both must be =< 5 x IULN); Participants must have a serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 28 days prior to sub-study randomization; Participants must have Zubrod performance status 0-1 documented within 28 days prior to sub-study randomization; Participants must provide pre-study history and physical exam within 28 days prior to sub-study randomization; Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within 28 days prior to sub-study randomization; Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load within 28 days prior to sub-study randomization; Participants with known human immunodeficiency virus (HIV) infection are eligible, provided they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to sub-study randomization; Participants must be able to swallow capsules; Participants must agree to have blood specimens submitted for circulating tumor DNA (ctDNA); Participants must also be offered participation in banking and in the correlative studies for collection and future use of specimens; Participants with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator); Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
Exclusion: Participants must not have leptomeningeal disease, spinal cord compression or brain metastases unless: (1) metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 14 days following treatment, and prior to sub-study randomization, AND (2) participant has no residual neurological dysfunction and has been off corticosteroids for at least 24 hours prior to sub-study randomization; Participants must not have received any prior systemic therapy (systemic chemotherapy, tyrosine kinase inhibitor [TKI], immunotherapy or investigational drug) within 14 days prior to sub-study randomization; Participants must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment while receiving treatment on this study. Concurrent use of hormones for non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement therapy) is acceptable; Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen; Participants must not have had a major surgery within 14 days prior to sub-study randomization. Participants must have fully recovered from the effects of prior surgery in the opinion of the treating investigator; Participants must not be pregnant or nursing. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen; Participants must not have any grade III/IV cardiac disease as defined by the New York Heart Association Criteria (i.e., participants with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia.