Pacing Method Tested to Prevent Persistent Atrial Fibrillation in Heart Rhythm Patients
Compares two heart pacing methods in adults with sinus node disease or AV block.
Plain-language title generated from the registry record
Registry title: Physiological Ventricular Pacing Vs Managed Ventricular Pacing for Persistent AF Prevention in Prolonged AV Interval
Key facts
- Where
- Rovigo, ItalySee the site
Where in Italy
- Elettrofisiologia, Cardiologia, Ospedale di RovigoRovigo, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Quovadis Associazione
- Trial code
- NCT05367037
- Record updated
- 11 May 2025
- Original description
A multicenter, prospective, randomized study in a 1:1 ratio, single-blind with double-blind evaluation to evaluate the superiority of physiological ventricular pacing (proposed modality) vs. managed ventricular pacing (control) for prevention of persistent AF (PeAF) occurrence in patients with prolonged atrioventricular interval (PR≥180 ms) and indication for pacing: sinus node disease and/or paroxysmal type 1 or 2-second degree AV block.Read full original descriptionShow less
Physiological Ventricular Pacing Versus Managed Ventricular Pacing for Persistent Atrial Fibrillation Prevention in Patients With Prolonged Atrioventricular Interval: a Multicenter RCT
A multicenter, prospective, randomized study in a 1:1 ratio, single-blind with double-blind evaluation to evaluate the superiority of physiological ventricular pacing (proposed modality) vs. managed ventricular pacing (control) for prevention of persistent AF (PeAF) occurrence in patients with prolonged atrioventricular interval (PR≥180 ms) and indication for pacing: sinus node disease and/or paroxysmal type 1 or 2-second degree AV block.
Inclusion: 18 years older patients, able to express Informed Consent, with prolonged atrioventricular interval (PR>180 ms) and one of the following indications for PM implantation according to current guidelines:; Sinus node disease; Paroxysmal type1or 2 second-degree AV-block.
Exclusion: Cardiac surgery < 3 months before PM implantation; Candidacy for implantable cardioverter-defibrillator or cardiac resynchronization therapy device implantation; History of long-standing persistent AF; Life expectancy of < 3 years; Severe grade mitral or aortic regurgitation/stenosis; Atrial fibrillation ablation (left pulmonary veins); Permanent third-degree AV block; Participation in another clinical trial in the past 3 months; Pregnancy or intention to become pregnant.