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Pacing Method Tested to Prevent Persistent Atrial Fibrillation in Heart Rhythm Patients

Compares two heart pacing methods in adults with sinus node disease or AV block.

Key facts

Who runs it
Quovadis Associazione
Where
Rovigo, ItalySee the site
Trial code
Registry title
Physiological Ventricular Pacing Vs Managed Ventricular Pacing for Persistent AF Prevention in Prolonged AV Interval
Status
Recruiting
People taking part
640 people, planned
Started
27 Jul 2022
Expected to end
Dec 2028
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • PhysioVP
  • DDD-VPA
Record updated
11 May 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who need a pacemaker for sinus node disease or intermittent second-degree AV block, and who have a prolonged PR interval.

Age
18 years or older
Sex
All sexes
Disease stage
Prolonged atrioventricular interval (PR>180 ms) and a pacemaker indication: sinus node disease or paroxysmal type 1 or 2 second-degree AV block.
Earlier treatment
No cardiac surgery in the 3 months before pacemaker implantation; no atrial fibrillation ablation of the left pulmonary veins.

Main reasons for not taking part

  • Needs an implantable cardioverter-defibrillator or cardiac resynchronization therapy device
  • Severe mitral or aortic valve regurgitation or stenosis
  • History of long-standing persistent atrial fibrillation
  • Permanent third-degree AV block
  • Pregnant or planning to become pregnant

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • 18 years older patients, able to express Informed Consent, with prolonged atrioventricular interval (PR>180 ms) and one of the following indications for PM implantation according to current guidelines:
  • Sinus node disease
  • Paroxysmal type1or 2 second-degree AV-block

Who cannot take part

  • Cardiac surgery < 3 months before PM implantation
  • Candidacy for implantable cardioverter-defibrillator or cardiac resynchronization therapy device implantation
  • History of long-standing persistent AF
  • Life expectancy of < 3 years
  • Severe grade mitral or aortic regurgitation/stenosis
  • Atrial fibrillation ablation (left pulmonary veins)
  • Permanent third-degree AV block
  • Participation in another clinical trial in the past 3 months
  • Pregnancy or intention to become pregnant

Where in Italy

  • Elettrofisiologia, Cardiologia, Ospedale di RovigoRovigo, ItalyContact: Gianni Pastore, MDTaking people

About the trial

What the trial wants to find out

A multicenter, prospective, randomized study in a 1:1 ratio, single-blind with double-blind evaluation to evaluate the superiority of physiological ventricular pacing (proposed modality) vs. managed ventricular pacing (control) for prevention of persistent AF (PeAF) occurrence in patients with prolonged atrioventricular interval (PR≥180 ms) and indication for pacing: sinus node disease and/or paroxysmal type 1 or 2-second degree AV block.

The 2 groups in the trial

  • PhysioVP groupExisting treatment, for comparison

    Physiological ventricular pacing

    Treatment: PhysioVP

  • DDD-VPA groupExisting treatment, for comparison

    Dual-chamber pacing with the addition of algorithms for ventricular pacing avoidance

    Treatment: DDD-VPA

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Physiological Ventricular Pacing Versus Managed Ventricular Pacing for Persistent Atrial Fibrillation Prevention in Patients With Prolonged Atrioventricular Interval: a Multicenter RCT
Plain-language title
Pacing Method Tested to Prevent Persistent Atrial Fibrillation in Heart Rhythm PatientsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
11 May 2025