NCT05368350Active, not recruiting
Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
Treating Primary Progressive Aphasia and Apraxia of Speech With High Definition Transcranial Direct Current Stimulation (HDtDCS-PPA/PAOS)
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area and left inferior frontal gyrus) thought to aid in memory will improve speech and language difficulties in patients with primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS). The primary outcome measures are neuropsychological assessments of speech and language functions, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 12 (actual)
- First submitted
- 5 May 2022
- Start date
- 1 Jun 2022
- Primary completion date
- 16 Apr 2027
- Lead sponsor
- The University of Texas at Dallas
- Diseases
- Frontotemporal dementia
- NCT number
- NCT05368350
What you commit to
- Study type: Interventional
- Participants enrolled: 12
- From 1 Jun 2022 to the primary completion date, 16 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has an implanted device, such as a pacemaker, metallic cranial implant, or a neurostimulator
- Currently receiving speech-language intervention
Other illness
- A significant history of arrhythmia or epileptic seizures.
Other
- Skull defects
- Pregnant
- Not a native English speaker
- Unable to communicated verbally
Who the study is looking for
- 18 to 85 years of age
- A formal diagnosis of primary progressive aphasia (nonfluent/agrammatic, semantic, logopenic variants or mixed) and/or progressive apraxia of speech
- Capable of understanding and signing an informed consent. Medical information/history, as well as mental status exam and diagnosis provided by referring physician will determine whether or not a caregiver is required to be involved during this process.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Texas at Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.