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Taking people in FranceNo phase

Efficacy of Surgical Joint Denervation in Painful Digital Osteoarthritis

Key facts

Who runs it
Assistance Publique - Hôpitaux de Paris
Where
Paris, FranceSee the site
Trial code
Status
Recruiting
People taking part
19 people, planned
Started
5 Jun 2023
Planned end
15 Jun 2026
Type of study
Interventional
Treatments tested
  • Surgical Denervation
Record updated
14 July 2025

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 17 criteriaShow less

Who can take part

  • Age ≥ 18 years
  • Patients with symptomatic digital osteoarthritis according to the criteria of the American College of Rheumatology
  • 1 painful PIP joint (Analog digital scale ≥ 4/10) for more than 3 months
  • having failed the usual medical treatment for a minimum of 3 months (level 1 analgesics, NSAIDs, infiltrations)
  • Signature of informed consent
  • patient affiliated to a social security scheme
  • knowing how to read French (for the questionnaires)

Who cannot take part

  • anesthetic contraindications to surgery or to performing an MRI
  • Use of oral, intramuscular or intra-articular or intravenous corticosteroids, immunosuppressants (methotrexate, sulfasalazine, leflunomide, biomedicines), hyaluronic acid infiltration in the finger joints in the previous month
  • Introduction of a new treatment for osteoarthritis of the hand in the previous month, including physiotherapy and fitting of a new finger orthosis
  • Participation in another interventional research involving the human person or period of exclusion at the end of a previous research involving the human person
  • Existence of a pain syndrome in the upper limbs, which would interfere with the assessment of AD
  • History of denervation of the proximal interphalangeal joint (PIP)
  • digital osteoarthritis secondary to other known causes (eg gout, reactive arthritis, RA, psoriatic arthritis, spondyloarthropathies, septic arthritis)
  • Fibromyalgia
  • Patient under legal protection (guardianship or curatorship) and patient deprived of liberty
  • Patient under AME

Where in France

  • Rheumatology department Saint-Antoine HospitalParis, FranceContact: Jérémie Sellam, Md PhD PU-PHTaking people

About the trial

What the trial wants to find out

Digital osteoarthritis is the second localization of symptomatic osteoarthritis, after the knee. Its cardinal symptoms are particularly intense pain and functional impairment in the case of the erosive form. There is currently no etiological treatment for osteoarthritis. Symptomatic treatments have a modest efficacy, which justifies the search for new treatments. The surgical options are arthrodesis or prosthesis, invasive techniques potentially sources of complications, and finally proposed infrequently given the prevalence of digital osteoarthritis.

Read full original descriptionShow less

DECAD is a prospective phase II trial aimed at evaluating the efficacy of surgical joint denervation in painful digital osteoarthritis.

The group in the trial

  • Surgical denervationTreatment being tested

    It consists of a section of the nerve branches destined for the PIPJ, coming from the digital collateral nerves as well as the dorsal sensory branches of the radial and ulnar nerves respectively for the index and fifth fingers.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Record updated
14 July 2025