Following People With Thoracic Aortic Aneurysm Over Time to Track Complications
Observes adults with a moderate chest aorta bulge to see how it changes.
Plain-language title generated from the registry record
Registry title: Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
Key facts
- Where
- Lille, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 80 years old?
Source: NCT05395598, who can take part
Where in France
- CHU LilleLille, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Lille
- Trial code
- NCT05395598
- Record updated
- 15 May 2026
- Original description
Thoracic aneurysm is a silent disease with a potential mid-term high risk of death or major complications. Few data are available on the real incidence of major complications in case of small and moderate thoracic aneurysm. Different factors are supposed to increase the risk of aortic enlargement as high blood pressure and sleep disorder breathing. The modality of imaging and clinical follow-up are well defined. In this prospective observational study, the aim to assess the incidence of of major complications during follow-up in a population of patients with a small or moderate thoracic aneurysm. The study will also try to identify systemic factors influencing aneurysm evolution.Read full original descriptionShow less
Predicting Moderate Thoracic Aortic Aneurysm Evolution: a Longitudinal Study of Systemic Factors in Patients Free of Connective Tissue Disease. .
Thoracic aneurysm is a silent disease with a potential mid-term high risk of death or major complications. Few data are available on the real incidence of major complications in case of small and moderate thoracic aneurysm. Different factors are supposed to increase the risk of aortic enlargement as high blood pressure and sleep disorder breathing. The modality of imaging and clinical follow-up are well defined. In this prospective observational study, the aim to assess the incidence of of major complications during follow-up in a population of patients with a small or moderate thoracic aneurysm. The study will also try to identify systemic factors influencing aneurysm evolution.
Inclusion: Documentation of an aortic root aneurysm > 40 mm; Agreement to participate to a longitudinal study and available for a 5 years follow-up.
Exclusion: Personal or family history of genetically documented elastic tissue disease or patient meeting the GAND clinical criteria suggestive of Marfan disease; High-grade mitra-aortic valve disease, even if asymptomatic; Unbalanced hypertension ≥ 180/110 mmHg; History of aortic surgery or endovascular intervention and history of type B aortic dissection of medical treatment; Renal insufficiency on dialysis, or GFR< 30 ml/mn (CKD-EPI); Presence of comorbidities or pathology with a prognosis of less than 1 year; Aneurysm (regardless of thoracic or abdominal location) ≥ 50 mm; Aneurysm (regardless of thoracic or abdominal location) with documented progression of more than 5 mm over one year.