Following People With Thoracic Aortic Aneurysm Over Time to Track Complications
Observes adults with a moderate chest aorta bulge to see how it changes.
Key facts
- Who runs it
- University Hospital, Lille
- Where
- Lille, FranceSee the site
- Trial code
- Registry title
- Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
- Status
- Recruiting
- People taking part
- 320 people, planned
- Started
- 18 Apr 2024
- Expected to end
- Oct 2031
- Type of study
- Observational
- Record updated
- 15 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a small or moderate aneurysm (a bulge) of the aortic root, who can be followed for 5 years.
- Age
- 45 to 80 years
- Sex
- Men and women can join.
- Disease stage
- An aortic root aneurysm larger than 40 mm. Aneurysms of 50 mm or more cannot join.
- Earlier treatment
- Anyone with earlier aortic surgery or an endovascular (inside the vessel) procedure cannot join.
Main reasons for not taking part
- Illness with an expected survival of less than 1 year
- Genetic connective tissue disease, or signs suggesting Marfan disease
- Severe heart valve disease, even without symptoms
- Uncontrolled high blood pressure of 180/110 mmHg or more
- Kidney failure on dialysis, or GFR below 30 ml/mn
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Documentation of an aortic root aneurysm > 40 mm
- Agreement to participate to a longitudinal study and available for a 5 years follow-up
Who cannot take part
- Personal or family history of genetically documented elastic tissue disease or patient meeting the GAND clinical criteria suggestive of Marfan disease
- High-grade mitra-aortic valve disease, even if asymptomatic
- Unbalanced hypertension ≥ 180/110 mmHg
- History of aortic surgery or endovascular intervention and history of type B aortic dissection of medical treatment
- Renal insufficiency on dialysis, or GFR< 30 ml/mn (CKD-EPI)
- Presence of comorbidities or pathology with a prognosis of less than 1 year
- Aneurysm (regardless of thoracic or abdominal location) ≥ 50 mm
- Aneurysm (regardless of thoracic or abdominal location) with documented progression of more than 5 mm over one year
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 80 years old?
Where in France
- CHU LilleLille, FranceContact: DELSART PascalTaking people
About the trial
What the trial wants to find out
Thoracic aneurysm is a silent disease with a potential mid-term high risk of death or major complications. Few data are available on the real incidence of major complications in case of small and moderate thoracic aneurysm. Different factors are supposed to increase the risk of aortic enlargement as high blood pressure and sleep disorder breathing. The modality of imaging and clinical follow-up are well defined. In this prospective observational study, the aim to assess the incidence of of major complications during follow-up in a population of patients with a small or moderate thoracic aneurysm. The study will also try to identify systemic factors influencing aneurysm evolution.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Predicting Moderate Thoracic Aortic Aneurysm Evolution: a Longitudinal Study of Systemic Factors in Patients Free of Connective Tissue Disease. .
- Plain-language title
- Following People With Thoracic Aortic Aneurysm Over Time to Track ComplicationsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05395598, who can take part
- Record updated
- 15 May 2026