Lowering Blood Lipids to Study Outcomes in Narrowed Brain Arteries
Tests a PCSK9 inhibitor to improve blood fat control in adults with brain artery narrowing.
Plain-language title generated from the registry record
Registry title: Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome
Key facts
- Where
- Nanjing, ChinaSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT05397405, who can take part
Where in China
- Nanjing First HospitalNanjing, ChinaTaking people
- Nanjing First Hospital, Nanjing Medical UniversityNanjing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Nanjing First Hospital, Nanjing Medical University
- Trial code
- NCT05397405
- Record updated
- 15 April 2026
- Original description
sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients (LDL-C>1.8mmol/L) without endovascular therapy.Read full original descriptionShow less
A Prospective Observational Study on the Effect of Improving Blood Lipid Management on the Clinical Prognosis of Symptomatic Intracranial Atherosclerotic Stenosis（sICASBLM）
sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients (LDL-C>1.8mmol/L) without endovascular therapy.
Inclusion: Age ≥18 years; Symptomatic intracranial atherosclerotic stenosis of moderate to severe, did not receive intravenous thrombolysis, thrombectomy, stent implantation and other intravascular treatment; low density lipoprotein cholesterol > 70mg/dl (1.8mmol/L); Receive 3T magnetic resonance angiography or multi-mode MR (high resolution is required), angiography can be included, and images for analysis can be obtained; Lipid-lowering indications of statins; Signed an approved informed consents.
Exclusion: Stenosis caused by vasculitis, arterial dissection and moyamoya disease; Patients with active bleeding or obvious bleeding tendency; Severe heart, lung, renal insufficiency, malignant tumor or other malignant diseases, and death is highly likely within 7 days; pregnancy or women who are lactating; Uncontrolled severe diabetes and hypertension; Other conditions inappropriate for inclusion judged by investigators; Contraindications to statins; There are contraindications to MRI examination or cannot accept MRI examination.