Tests fish oil to prevent oxaliplatin nerve damage after colorectal cancer surgery
Tests fish oil supplements against nerve damage from chemotherapy in colorectal cancer patients.
Plain-language title generated from the registry record
Registry title: Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities
Key facts
- Where
- Aalborg, Aarhus, Sønderborg, and Vejle, DenmarkSee the 4 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with colon or rectal cancer who are planned to get capecitabine with oxaliplatin after surgery. It tests whether fish oil supplements protect the nerves in the hands and feet.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Adenocarcinoma of the colon or rectum, confirmed by tissue examination, with planned standard treatment after surgery (capecitabine with oxaliplatin). ECOG performance status 0-2.
- Earlier treatment
- No earlier treatment with chemotherapy that is toxic to the nerves.
Main reasons for not taking part
- Cannot speak, read and understand Danish
- Nerve or mental health disorders, diabetes or other significant medical conditions
- Numbness or other sensory problems in the feet
- Known allergy to fish, fish oil or corn oil
- Does not agree to a skin biopsy
Read by machine on 9 November 2026.
Where in Denmark
- Department of Oncology, AAUHAalborg, DenmarkTaking people
- Department of Oncology, AUHAarhus, DenmarkTaking people
- Department of OncologySønderborg, DenmarkTaking people
- Department of Oncology, Vejle HospitalVejle, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Vejle Hospital
- Trial code
- NCT05404230
- Record updated
- 19 May 2026
- Original description
The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.Read full original descriptionShow less
Prevention of Oxaliplatin-induced Peripheral Neuropathy - a Randomized Controlled Trial
The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.
Inclusion: Histopathologically verified adenocarcinoma of the colon or rectum and planned standard adjuvant treatment with capecitabine in combination with oxaliplatin; ECOG performance status 0-2 (measurement of a patient's function in terms of self-care, daily activity and physical ability; Written and orally informed informed consent.
Exclusion: Previous treatment with neurotoxic chemotherapy; Alcohol or drug abuse; Neurological (including neuropathy) or psychiatric disorders, diabetes or other significant medical conditions; Vascular disease (Fontaine grade II or more); Known allergy to fish, fish oil or corn oil; Inability to speak, read, and understand Danish; Sensory disturbances in the feet; Spinal stenosis; Fertile patients not willing to use effective methods of contraception during treatment or abstinence; Daily intake of oil supplements and not willing to stop during the trial period; Lack of consent to skin biopsy.