Tests fish oil to prevent oxaliplatin nerve damage after colorectal cancer surgery
Tests fish oil supplements against nerve damage from chemotherapy in colorectal cancer patients.
Plain-language title generated from the registry record
Registry title: Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities
Key facts
- Where
- Aalborg, Aarhus, Sønderborg, and Vejle, DenmarkSee the 4 sites
Where in Denmark
- Department of Oncology, AAUHAalborg, DenmarkTaking people
- Department of Oncology, AUHAarhus, DenmarkTaking people
- Department of OncologySønderborg, DenmarkTaking people
- Department of Oncology, Vejle HospitalVejle, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Vejle Hospital
- Trial code
- NCT05404230
- Record updated
- 19 May 2026
- Original description
The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.Read full original descriptionShow less
Prevention of Oxaliplatin-induced Peripheral Neuropathy - a Randomized Controlled Trial
The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.
Inclusion: Histopathologically verified adenocarcinoma of the colon or rectum and planned standard adjuvant treatment with capecitabine in combination with oxaliplatin; ECOG performance status 0-2 (measurement of a patient's function in terms of self-care, daily activity and physical ability; Written and orally informed informed consent.
Exclusion: Previous treatment with neurotoxic chemotherapy; Alcohol or drug abuse; Neurological (including neuropathy) or psychiatric disorders, diabetes or other significant medical conditions; Vascular disease (Fontaine grade II or more); Known allergy to fish, fish oil or corn oil; Inability to speak, read, and understand Danish; Sensory disturbances in the feet; Spinal stenosis; Fertile patients not willing to use effective methods of contraception during treatment or abstinence; Daily intake of oil supplements and not willing to stop during the trial period; Lack of consent to skin biopsy.