Comparing two procedures to treat irregular heartbeat with heart failure
Tests two heart procedures for persistent atrial fibrillation in adults with heart failure.
Plain-language title generated from the registry record
Registry title: Hybrid Ablation of Atrial Fibrillation in Heart Failure
Key facts
- Where
- Chertsey, Epsom, and London, United KingdomSee the 7 sites
Where in United Kingdom
- Ashford & St Peters Hospital NHS TrustChertsey, United KingdomTaking people
- Epsom General HospitalEpsom, United KingdomTaking people
- Royal Surrey County HospitalLondon, United KingdomTaking people
- St Georges at Kingston HospitalLondon, United KingdomTaking people
- St Georges University of LondonLondon, United KingdomTaking people
- Cromwell HospitalLondon, United KingdomNo longer taking part
- St Anthonys HospitalLondon, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- St. George's Hospital, London
- Trial code
- NCT05411614
- Record updated
- 28 November 2025
- Original description
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart FailureRead full original descriptionShow less
A Randomised Controlled Trial Comparing Convergent Hybrid Ablation to Catheter Ablation in Patients With Persistent Atrial Fibrillation and Heart Failure
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure
Inclusion: Age ≥ 18 years; Persistent or Long-standing Persistent AF; Dilated left atrium (at least moderately dilated); Suitable for either procedure; LVEF < 50%.
Exclusion: Previous open-heart surgery; Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable); Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures; Not yet optimised from a medical or lifestyle perspective for AF or heart failure; Active infection, oesophageal ulcer stricture or oesophageal varices; Severe valvular heart disease; Unstable coronary artery disease; Uncontrolled ventricular arrhythmia; Heart attack or stroke within the last 90 days; Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months; Unable to provide written consent; Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation.