Taking people in United StatesPhase 4
Tests a lower weekly prednisolone dose in young boys with Duchenne muscular dystrophy
Tests whether a lower weekly prednisolone dose works as well in young boys with Duchenne.
Plain-language title generated from the registry record
Registry title: Once Weekly Infant Corticosteroid Trial for DMD
Key facts
- Where
- Chicago, Cincinnati, Columbus, and Dallas, United StatesSee the 4 sites
- Phase
- Phase 4
Where in United States
- Lurie Children's Hospital of ChicagoChicago, United StatesTaking people
- University of CincinnatiCincinnati, United StatesTaking people
- Nationwide Children's HospitalColumbus, United StatesTaking people
- University of Texas, SouthwesternDallas, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Anne M. Connolly
- Trial code
- NCT05412394
- Record updated
- 14 August 2026
- Original description
The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose.Read full original descriptionShow less
Phase-2 Trial of 5mg/kg/Week Prednisolone in Young Boys With DMD
The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose.
Inclusion: Subjects ages 1 month through 30 months; Weakness consistent with Duchenne on exam, creatine kinase ≥ 20 times the upper limit of normal, and genetic mutation known to be causative for DMD.
Exclusion: Prior treatment with Glucocorticosteroids.