Testing Urine for HPV to Screen for Cervical Cancer in Women With HIV
Checks whether urine samples can detect cervical cancer risk in women living with HIV.
Plain-language title generated from the registry record
Registry title: Urine HPV Testing for Cervical Cancer Screening Among Women Living With HIV in South Africa
Key facts
- Where
- Westdene, South AfricaSee the site
Where in South Africa
- Clinical HIV Research Unit Temba Lethu Wing Helen Joseph HospitalWestdene, South AfricaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- UNC Lineberger Comprehensive Cancer Center
- Trial code
- NCT05413798
- Record updated
- 30 September 2026
- Original description
The purpose of this study explores the usefulness of urine samples for cervical cancer screening in human immunodeficiency virus (HIV)-infected women.Read full original descriptionShow less
Clinical Performance Validation of Urine HPV Testing for Cervical Cancer Screening Among Women Living With HIV in South Africa
The purpose of this study explores the usefulness of urine samples for cervical cancer screening in human immunodeficiency virus (HIV)-infected women.
Cervical cancer occurs when women are infected with the human papillomavirus (HPV), which can cause changes in the cells that lead to cervical precancer and, eventually, cervical cancer if untreated. However, urine HPV testing has not been well validated low- and middle-income country settings, with no data available to guide its use in HIV-infected women.
Inclusion: In order to participate in this study a subject must meet all of the eligibility criteria outlined below; Confirmed HIV-1 infection; Age 25 years and older; Be willing and able to provide written informed consent.
Exclusion: Have been screened for cervical cancer within the preceding year (365 days); Have an active sexually transmitted infection (STI; women may participate once treated); Have a history of cervical cancer; Pregnant or intend to become pregnant within 90 days of enrollment; Have a surgically absent cervix; have been vaccinated against HPV.