The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia
Key facts
- Who runs it
- Jessa Hospital
- Where
- Belgium1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Terminated
- People taking part
- 165 people enrolled
- Started
- 17 Oct 2022
- Ended
- 9 Nov 2024
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Discontinued ventilation
- Continued ventilation
- Record updated
- 29 November 2024
- Why it stopped
- After the passing of the principal investigator, the clinical trial could not be continued.
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Patients older than 18 years old
- Patients undergoing their first elective endo-CABG procedure using peripheral cannulation for CPB
- Patients who are able to give their informed consent
- Patients who speak Dutch or French
Who cannot take part
- Patients taking corticosteroids
- Patients with lung diseases (chronic obstructive pulmonary disease (COPD), asthma)
- Patients with an ejection fraction < 25%
- Patients participating in another clinical trial
- Patients where groin cannulation is not possible
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this study is to examine the influence of mechanical ventilation on the occurrence of myocardial ischemia in patients undergoing endo-CABG.
The 2 groups in the trial
- Control groupExisting treatment, for comparison
Ventilation is discontinued after going on CPB and lungs are exposed to atmospheric pressure. Blood will be drawn: At baseline: before general anaesthesia, after start of CPB, after clamping the aorta, before unclamping the aorta, after the operation, 5 h after clamping the aorta, 12 hours after clamping the aorta, and 24 hours after aortic clamping
Treatment: Discontinued ventilation
- Ventilation groupTreatment being tested
Ventilation is continued from going on CPB until clamping of the ascending aorta. Blood will be drawn: At baseline: before general anaesthesia, after start of CPB, after clamping the aorta, before unclamping the aorta, after the operation, 5 h after clamping the aorta, 12 hours after clamping the aorta, and 24 hours after aortic clamping
Treatment: Continued ventilation
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia in Patients Undergoing Totally Endoscopic Coronary Artery Bypass Grafting
- Record updated
- 29 November 2024