NCT05421455Recruiting
Surgery vs Biologics for Treating Stricturing CD--a RCT
Surgery Versus Biologics for Symptomatic Stricturing Crohn's Disease : an Open-label, Single-center, Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 9 Jul 2026
Brief summary (registry, in English)
The management of stricturing Crohn's disease (CD) remains challenging. Although surgical resection may be the final way to solve it, the efficacy of biologics for symptomatic CD associated strictures was acceptable. In clinical practice, the chioce of treatment is particularly difficult. Therefore, a clinical trial of biologics versus surgery is needed to assess which one is prefered.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 138 (estimated)
- First submitted
- 9 Jun 2022
- Start date
- 9 Jun 2022
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Zhu Weiming
- Diseases
- Crohn's disease
- NCT number
- NCT05421455
What you commit to
- Study type: Interventional
- Planned participants: 138
- From 9 Jun 2022 to the primary completion date, 1 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- successful treatment with traditional drugs;
Other illness
- penetrating disease;
Other
- unsuccessful medical treatment of intestinal obstruction;
- complete obstruction;
- contraindication for biologics;
- short smaal bowel;
- suspicion of bowel tumor;
- no confirmed strictures;
- comitant severe disese of other system;
- obstructive symptoms under over 2 targets of biologics;
- participate other clinical research.
Who the study is looking for
- with intestinal obstructive symptoms;
- confirmed intestinal strictures;
- traditional drugs failed to induce remission;
- envidence of active bowel inflammation;
- inappropriate for EBD;
- acquirement of written informed consent of participant;
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of General Surgery, Jinling hosptal,Medical School of Nanjing University Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.