Effects of Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis
Key facts
- Who runs it
- Bispebjerg Hospital
- Where
- Denmark1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 96 people enrolled
- Started
- 1 Jan 2022
- Ended
- 14 Feb 2025
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- BFR (Blood-Flow Restricted exercise)
- Standard rehabilitation
- Record updated
- 29 June 2025
Who can take part
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 20 criteriaShow less
Who can take part
- All participants must meet the American College of Rheumatology (ACR) criteria for OA 35
- Visible OA on X-ray pictures (Kellgren \& Lawrence grade 2-3)
- Unilateral pain and functional limitation for a minimum of 3 months
- Be able to voluntarily (i.e. unassisted) perform a 90 degrees flexion in the knee
- Be able to perform the machine exercise (knee extension) planned for the BFR training
- Danish-speaking
- No longer travel planned within the intervention period
Who cannot take part
- Prior knee- or hip alloplasty
- Prior myocardial infarct or apoplexy, or chest pain during physical activity
- Prior history of deep venous thrombosis
- Known neurotic disease such as multiple sclerosis or peripheral neuropathy
- Other health related or medical conditions which makes it impossible participate in the study; Furthermore, it is an exclusion criterium in the following conditions where use of pneumatic occlusion would be considered contraindicated:
- Peripheral vascular disease
- Venous insufficiency causing edema in the lower legs
- Kellgren \& Lawrence grade 4
- Bilateral OA-symptoms
- Glucocorticosteroid injection in the knee within the last 6 months
- Inflammatory arthritis
- Excessive varicose veins
- Systolic blood pressure over 160 mmHg or under 100 mmHg
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The purpose of this study is to investigate the effect of low-intensity BFR exercise on joint pain, muscle mass, and mechanical muscle function compared to standard rehabilitering in adults with knee-OA.
The 2 groups in the trial
- BFR (Blood-Flow Restricted exercise)Treatment being tested
The BFR training intervention group will perform low load blood-flow restricted exercise. Training twice a week for 12 weeks. The group will also attend a two hours education lecture with osteoarthritis information.
- Standard rehabilitationExisting treatment, for comparison
The standard rehabilitation group will be offered participation in the Good Life with osteoArthritis in Denmark programme (GLA:D). The programme includes supervised team group training twice a week for 8 weeks and an education lecture. The GLA:D programme will be followed by 4 weeks of team group training continuing the exercises from the GLA:D programme.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effects of Low-intensity Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis - a Randomized Controlled Trial
- Record updated
- 29 June 2025