NCT05443633Recruiting
Enhancing Language Function in Aphasia
Enhancing Language Function in Aphasia Using Behavioral Language Intervention
Source: ClinicalTrials.gov · Last updated 9 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain). This impairment is seen in many aspects of language, including understanding, speaking, reading and writing. It is estimated that about 2 million individuals are currently living with aphasia in the United States. Further, about 200,000 Americans acquire aphasia every year (National Aphasia Association, 2020). Aphasia poses significant impact on the affected individuals and their families. Behavioral treatments that target language deficits have been shown to enhance overall communication skills and life satisfaction among individuals with aphasia. Although there is evidence that suggests that treatment is efficacious for individuals with aphasia, the extent of improvement long-term coupled with the neural patterns among those individuals are largely unknown. The current study aims to investigate the efficacy of language-based treatment and its corresponding neural patterns.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 29 Jun 2022
- Start date
- 30 Oct 2022
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- University of Arizona
- Diseases
- Frontotemporal dementia, Stroke
- NCT number
- NCT05443633
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 30 Oct 2022 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals with highly magnetizable metallic implants, including certain dental work, may be excluded due to image quality in MRI.
- Individuals who have had a brain surgery in the past
- Individuals with implanted metallic skull plates or intracranial implants
- Individuals with severe non-linguistic cognitive disturbances impeding language therapy
Other illness
- Individuals diagnosed with mood, anxiety, psychotic or substance abuse disorders.
- Individuals with other neurological disorders besides the ones of interest for the study (e.g., epilepsy, Multiple Sclerosis, Parkinson's Disease)
- Individuals with contraindications for MRI. This includes but is not limited to pacemakers, metallic cardiac pumps, valves, magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.
- Severe systemic disease (e.g., renal failure)
- Individuals with a history of epileptic activity in the past 12 months
- Individuals with a personal or family history of epilepsy or other seizure disorders will not be included in the study.
- Individuals who have a history of excessive use of alcohol or drugs
- Individuals with premorbid psychiatric disease affecting communication
Other
- Individuals suffering from clinically significant claustrophobia
- Poor overall health
- Individuals who are pregnant
- Individuals with skin lesions or skull damage
Who the study is looking for
- Present with speech-language impairment (aphasia) caused by stroke or dementia
- A medical diagnosis of primary progressive aphasia (PPA) by a neurologist or physician
- Are native speakers of English
- Present with no contraindications for MRI
- Have adequate (normal or corrected to normal) vision and hearing
Age in the registry: 21 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Arizona Coordinator of this site? Confirm its status | Tucson | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.