CompletedNo phase
Treatment of Osteoarthritis of the Hip Joint With Intra-articular Injection of Microfractured Autologous Adipose Tissue Containing Mesenchymal Stromal Cells.
Key facts
- Who runs it
- Istituto Ortopedico Rizzoli
- Where
- Italy1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 30 people enrolled
- Started
- 24 Oct 2022
- Ended
- 17 Dec 2025
- Type of study
- Interventional
- Treatments tested
- Micro-fragmented adipose tissue injection
- Record updated
- 3 February 2026
Who can take part
- Age
- 40 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 19 criteriaShow less
Who can take part
- Age between 40 and 70 years
- Signs and symptoms of hip OA (pain intensity of at least 4 points and not more than 8 of VAS pain - 0-10 scale in the previous week)
- Radiographic signs of hip OA (Grade 1-2 according to Tonnis classification) or MRI signs (chondropathy or minimal labrum degeneration without acute lesions) even if Grade 0
- Unilateral involvement
- Ability and consent of patients to actively participate in clinical follow-up
- Signature of informed consent
Who cannot take part
- Patients undergoing infiltration of other substance in the previous 6 months
- Patients undergoing lower limb surgery to be treated in the previous 12 months
- Patients abusing alcoholic beverages, drugs or medications
- Previous extensive surgery of the reference joint (osteotomy around the hip, open or arthroscopic osteochondroplasty for femoro-acetabular conflict)
- Patients with malignant neoplasms
- Patients with rheumatic diseases
- Patients with uncontrolled diabetes
- Patients with uncontrolled thyroid metabolic disorders
- Patients with other hip pathologies: acetabular protrusion, concentric migration of the femoral head, presence of excessive deformity resulting from acetabular or femoral head dysplasia, collapse deformity, and deformed femoral head sequelae of Perthes disease or osteonecrosis of the femoral head
- Patients unable to express consent
- Body Mass Index > 35
- Pregnant and/or fertile women
- Pain intensity less than 4 points or greater than 8 in accordance with the VAS scale
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The aim of the study is to evaluate the safety and efficacy up to 12 months of MF-AT in the echo-guided infiltrative treatment of hip OA through clinical, subjective and objective evaluations.
The group in the trial
- MF-AT injectionTreatment being tested
Patients will be treated with an intra-articular-ultrasound-guided injection of Micro-fragmented adipose tissue containing mesenchymal stromal cells.
Treatment: Micro-fragmented adipose tissue injection
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Interventional Pilot Study on the Treatment of Osteoarthritis of the Hip Joint With Intra-articular Ultrasound-guided Infiltration of Microfractured Autologous Adipose Tissue Containing Mesenchymal Stromal Cells
- Record updated
- 3 February 2026