Tracks brain small vessel disease with genetic and MRI testing
Follows people with small vessel brain disease, using genetic testing and MRI scans.
Plain-language title generated from the registry record
Registry title: Taiwan Associated Genetic and Nongenetic Small Vessel Disease
Key facts
- Where
- Taipei, TaiwanSee the site
Where in Taiwan
- Department of Neurology, National Taiwan University HospitalTaipei, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Taiwan University Hospital
- Trial code
- NCT05473637
- Record updated
- 20 January 2026
- Original description
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.Read full original descriptionShow less
Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.
Inclusion: Participants must have at least one of the following symptoms/signs or history; stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke); cognitive impairment or dementia; gait disturbance; parkinsonism (especially vascular parkinsonism features); headache (especially migraine); positive family history of hereditary CSVD; MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed.
Exclusion: MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions; patients or family members not willing to sign informed consent.