Studying kidney disease caused by metabolic conditions and its risk factors
Builds a patient group with kidney disease from hypertension, diabetes, obesity or uric acid.
Plain-language title generated from the registry record
Registry title: Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 80 with a confirmed metabolic disease, such as high blood pressure, diabetes, high uric acid or obesity, who have chronic kidney disease.
- Age
- 18 to 80 years
- Sex
- Women and men can join.
- Disease stage
- A confirmed metabolic disease. The study builds a group of people with chronic kidney disease caused by metabolic diseases.
Main reasons for not taking part
- Primary or secondary glomerular kidney disease
- Other conditions that change the kidney, such as kidney cysts, polycystic kidney disease, hydronephrosis, renal artery stenosis or kidney tumors
- Cannot have an MRI scan
- Pregnant or breastfeeding
- Unstable vital signs, failure of other organs or restlessness
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT05476627, who can take part
Where in China
- Peking Union Medical College HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Peking Union Medical College Hospital
- Trial code
- NCT05476627
- Record updated
- 16 August 2022
- Original description
With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an important health burden in China. The pathophysiological mechanism of renal injury caused by metabolic diseases has always been a hotspot of research. Currently, it is believed that various mechanisms including the activation of Renin-Angiotensin-Aldosterone System, vascular endothelial dysfunction, oxidative stress and inflammatory process may be involved. Although there are differences in renal pathological manifestations caused by different metabolic diseases, the kidney will eventually present ischemic changes and fibrosis with the progression of the disease. So there must be some common pathogenesis. This study is designed to build a disease cohort of patients with chronic kidney disease caused by metabolic diseases, to identify risk factors leading to disease progression and to explore biomarkers for early diagnosis and treatment of kidney damage.Read full original descriptionShow less
Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases
With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an important health burden in China. The pathophysiological mechanism of renal injury caused by metabolic diseases has always been a hotspot of research. Currently, it is believed that various mechanisms including the activation of Renin-Angiotensin-Aldosterone System, vascular endothelial dysfunction, oxidative stress and inflammatory process may be involved. Although there are differences in renal pathological manifestations caused by different metabolic diseases, the kidney will eventually present ischemic changes and fibrosis with the progression of the disease. So there must be some common pathogenesis. This study is designed to build a disease cohort of patients with chronic kidney disease caused by metabolic diseases, to identify risk factors leading to disease progression and to explore biomarkers for early diagnosis and treatment of kidney damage.
Inclusion: The diagnosis of metabolic diseases were confirmed; Be able to understand the process of the research; Volunteer for participation and be able to sign the informed consent.
Exclusion: Patients with primary and secondary glomerular diseases; Patients with other comorbidities that could affect the volume or the components of the kidney, such as renal cysts, polycystic kidney disease, medullary sponge kidney, hydronephrosis, renal artery stenosis, renal vein thrombosis and/or renal tumors; Patients with unstable vital signs, failure of other organs or dysphoria; Age <18 yrs or >80yrs; Contraindications for MRI examination; Pregnant or lactation patients.