Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
Key facts
- Who runs it
- Boston Children's Hospital
- Where
- Waltham, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 43 people enrolled
- Started
- 17 Oct 2022
- Ended
- 30 Nov 2023
- Type of study
- Observational
- Record updated
- 26 June 2024
Who can take part
- Age
- 10 years to 17 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- age 10-17 years
- first test completed within 5 days of admission
- established diagnosis of primary or secondary chronic pain
- report of constant moderate pain (≥ 5/10 on a numeric rating scale of 0-10 points) for at least 3 months duration
- stable use of medications for at least one week prior to the study visit
Who cannot take part
- a history of central nervous system, heart, kidney, liver and respiratory system diseases, and psychiatric disorders (e.g., bipolar, conversion, psychosis)
- presence of allodynia in either upper extremity
- reported consumption of alcohol, cannabis or tobacco products
- unable to read English or follow testing instructions
- intolerant to the thermal test stimulus, or vi) no pain reported at maximum stimulus (48ºC)
Where in United States
- Boston Children's Hospital at WalthamWaltham, United StatesNo longer taking part
About the trial
What the trial wants to find out
This work will answer two critical questions: 1) Does intensive interdisciplinary pain treatment (IIPT) involving aerobic exercise help normalize pain processing in youth with chronic pain syndromes and 2) Are aerobic fitness levels and the ability to modulate pain inter-related?
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Currently, medications are ineffective for improving pain and disability in youth with chronic pain syndromes and identifying non-pharmacologic treatments, such as IIPT, that help strengthen the nervous system's ability to modulate or turn pain signals down will improve outcomes and quality of life for youth suffering from chronic pain. This study will help determine whether exercise based IIPT leads to physiologic improvements in how pain is processed, specifically if youth with chronic pain can better turn pain down during the offset analgesia test after an exercise based IIPT treatment, and also help elucidate the link between a child's aerobic fitness and their ability to modulate pain.
The group in the trial
- Youth with Chronic pain
We will recruit 38 youth with primary and secondary chronic pain syndromes\[29; 31\] ages 10-17 years who are admitted to the Mayo Family Pediatric Pain Rehabilitation Center at Boston Children's Hospital. This longitudinal cohort study will examine responses to the OA and Fitkids Treadmill tests at 2 timepoints: 1) within 5 days of IIPT admission and 2) within 1 week of IIPT discharge. Twelve participants will complete a 3rd visit within 5 days of the first study visit to examine OA test-retest reliability.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 26 June 2024